Indole-3-glycerol-phosphate lyase explained

Indole-3-glycerol-phosphate lyase
Ec Number:	4.1.2.8

The enzyme indole-3-glycerol-phosphate lyase catalyzes the chemical reaction

(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate

\rightleftharpoons indole + D-glyceraldehyde 3-phosphate

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (1S,2R)-1-C-(indol-3-yl)glycerol-3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming). Other names in common use include tryptophan synthase alpha, TSA, indoleglycerolphosphate aldolase, indole glycerol phosphate hydrolase, indole synthase, indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase, indole-3-glycerol phosphate lyase, IGL, BX1, (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate, and D-glyceraldehyde-3-phosphate-lyase. This enzyme participates in benzoxazinone biosynthesis.

References

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• Melanson D, Chilton MD, Masters-Moore D, Chilton WS . 1997 . A deletion in an indole synthase gene is responsible for the DIMBOA-deficient phenotype of bxbx maize . Proc. Natl. Acad. Sci. U.S.A. . 94 . 13345 - 50 . 9371848 . 10.1073/pnas.94.24.13345 . 24 . 24311 . 1997PNAS...9413345M . free .