| State: | IN |
| Type: | IN |
| Route: | 450 |
| Map Custom: | yes |
| Map Notes: | SR 450 highlighted in red |
| Length Mi: | 24.956 |
| Established: | 1932[1] |
| Counties: | Martin, Lawrence |
| Direction A: | West |
| Terminus A: | near Shoals |
| Direction B: | East |
| Terminus B: | at Bedford |
| Previous Type: | IN |
| Previous Route: | 446 |
| Next Type: | IN |
| Next Route: | 458 |
State Road 450 is a winding route in southern Indiana that terminates at both ends at its parent route, U.S. Route 50. It covers a distance of about 25miles.
State Road 450 begins just north of the town of Shoals in Martin County and runs northeast to rejoin U.S. Route 50 in Bedford in Lawrence County.