| State: | IN |
| Type: | IN |
| Route: | 161 |
| Map Custom: | yes |
| Map Notes: | SR 161 highlighted in red |
| Length Mi: | 49.691 |
| Established: | 1931[1] |
| Direction A: | South |
| Terminus A: | near Owensboro, KY |
| Junction: | near Dale |
| Direction B: | North |
| Terminus B: | near Huntingburg |
| Counties: | Dubois, Spencer, Warrick |
| Previous Type: | IN |
| Previous Route: | 160 |
| Next Type: | IN |
| Next Route: | 162 |
State Road 161 in the U.S. State of Indiana is a rural undivided north - south highway in the southwestern portion of the state.
State Road 161 begins in Spencer County approximately nine miles southwest of Rockport at the northern end of the Owensboro Bridge across the Ohio River in the Ohio Township. It goes north to Reo. Which passes into Warrick County, where it has concurrencies with State Road 62 and State Road 68. At the north end of the county it passes over Interstate 64 three times in five miles (8 km), but the only interchange is at the last overpass. State Road 161 ends in Dubois County at State Road 64 approximately four miles west of Huntingburg.
The route of SR 161 was extended by nearly 12miles in the fall of 2002 when the Indiana Department of Transportation redesignated the former route of U.S. Route 231 in Spencer County.