Indeterminate cell histiocytosis explained
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| Synonyms: | Indeterminate dendritic cell tumor |
| Field: | Dermatology |
Indeterminate cell histiocytosis (LCH) is an uncommon proliferative illness where the predominant cells have characteristics from both non-Langerhans cell histiocytosis (NLCH) and Langerhans cell histiocytosis (LCH) in terms of morphology and immunophenotypic characteristics.[1] Wood et al. originally described ICH in 1985 as a neoplastic disease arising from dermal indeterminate cells that lack Birbeck granules but are characteristically positive for S-100 and CD1a.[2]
Signs and symptoms
Clinically, ICH is defined by pink to reddish, varying-sized, painless, non-itching papules or nodules that develop on otherwise healthy skin (sparing mucosae). These lesions can appear as a single, distinct group of lesions, or several generalized papules dispersed over the trunk, face, and limbs. They can also show signs of stable disease, remission and recurrence, or spontaneous remission.[3]
Causes
Possible causes include scabies,[4] mosquito bites,[5] and a clonal drive.[6]
Treatment
Treatment include 5% 5-fluorouracil cream, topical pure coal tar, electron beam therapy, phototherapy, and total excision.[7] [8]
See also
Further reading
- Wang . Chun-Hua . Chen . Gwo-Shing . Indeterminate Cell Histiocytosis: A Case Report . The Kaohsiung Journal of Medical Sciences . Wiley . 20 . 1 . 2004 . 1607-551X . 10.1016/s1607-551x(09)70080-4 . 24–29 . 15481563 . none. free .
- Zanella . Simone . Berti . Emilio . Bonometti . Arturo . for Associazione Italiana Ricerca Istiocitosi ONLUS . Indeterminate cell histiocytosis: A systematic review of the literature with a comprehensive revision of clinical, histopathological, and molecular features . Journal of the European Academy of Dermatology and Venereology . 37 . 8 . 2023 . 0926-9959 . 10.1111/jdv.19095 . 1559–1575 . 37016977 . 257954148 . none.
External links
Notes and References
- Vener . C. . Soligo . D. . Berti . E. . Gianelli . U. . Servida . F. . Ceretti . E. . Caputo . R. . Passoni . E. . Lambertenghi Deliliers . G. . Indeterminate cell histiocytosis in association with later occurrence of acute myeloblastic leukaemia . British Journal of Dermatology . Oxford University Press (OUP) . 156 . 6 . 2007 . 0007-0963 . 10.1111/j.1365-2133.2007.07880.x . 1357–1361. 17459045 . 41005413 .
- WOOD . GARY S. . HU . CHUNG-HONG . BECKSTEAD . JAY H. . TURNER . RODERICK R. . WINKELMANN . R. K. . The Indeterminate Cell Proliferative Disorder: Report of a Case Manifesting as an Unusual Cutaneous Histiocytosis . The Journal of Dermatologic Surgery and Oncology . Wiley . 11 . 11 . 1985 . 0148-0812 . 10.1111/j.1524-4725.1985.tb01399.x . 1111–1119. 3902927 .
- Zerbini . Maria Claudia Nogueira . Sotto . Mirian Nacagami . Campos . Fernando Peixoto Ferraz de . Abdo . Andre Neder Ramires . Pereira . Juliana . Sanches . José Antônio . Martins . Jade Cury . Indeterminate cell histiocytosis successfully treated with phototherapy . Autopsy and Case Reports . Editora Cubo . 6 . 2 . 2016 . 2236-1960 . 10.4322/acr.2016.038 . 33–38. 27547741 . 4982782 .
- Hashimoto . Ken . Fujiwara . Keiko . Punwaney . Juanita . DiGregorio . Fiorino . Bostrom . Paul . El-Hoshy . Khaled . Aronson . Peter J. . Schoenfeld . Robert J. . Post-Scabetic Nodules: A Lymphohistiocytic Reaction Rich in Indeterminate Cells . The Journal of Dermatology . Wiley . 27 . 3 . 2000 . 0385-2407 . 10.1111/j.1346-8138.2000.tb02148.x . 181–194. 10774146 . 23463988 .
- Mo . Xianglan . Guo . Wenwen . Ye . Hongtao . Primary Indeterminate Dendritic Cell Tumor of Skin Correlated to Mosquito Bite . Medicine . Ovid Technologies (Wolters Kluwer Health) . 94 . 34 . 2015 . 0025-7974 . 10.1097/md.0000000000001443 . e1443. 26313805 . 4602924 .
- Brown . Ryanne A. . Kwong . Bernice Y. . McCalmont . Timothy H. . Ragsdale . Bruce . Ma . Lisa . Cheung . Christine . Rieger . Kerri E. . Arber . Daniel A. . Kim . Jinah . ETV3-NCOA2 in indeterminate cell histiocytosis: clonal translocation supports sui generis . Blood . American Society of Hematology . 126 . 20 . November 12, 2015 . 0006-4971 . 10.1182/blood-2015-07-655530 . 2344–2345. 26438513 .
- Miracco . Clelia . Raffaelli . Miranda . de Santi . Maria . Margherita . M.S . Fimiani . Michele . Tosi . Piero . Solitary cutaneous reticulum cell tumor. Enzyme-immunohistochemical and electron-microscopic analogies with IDRC sarcoma . The American Journal of Dermatopathology . February 1988 . 10 . 1 . 47–53 . 10.1097/00000372-198802000-00006 . 2845833 . 24 January 2024.
- Berti . Emilio . Unusual Cutaneous Histiocytosis Expressing an Intermediate Immunophenotype Between Langerhans' Cells and Dermal Macrophages . Archives of Dermatology . American Medical Association (AMA) . 124 . 8 . August 1, 1988 . 0003-987X . 10.1001/archderm.1988.01670080062020 . 1250. 3401031 .
