Immunoglobulin C1-set domain explained

C1-set domains are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules,^{[1] [2]} and in various T-cell receptors.

Human proteins containing this domain

AZGP1

B2M; CD1A; CD1B; CD1C; CD1D; CD1E; DMA;DQB2

DRB1; ELK2P1; FCGRT; HFE; HHLA2; HLA-A; HLA-B

HLA-B35; HLA-B57; HLA-C; HLA-CW; HLA-Cw; HLA-D;HLA-DMA

HLA-DMB; HLA-DOA; HLA-DOB; HLA-DP; HLA-DPA1; HLA-DPB1; HLA-DQA1;HLA-DQA2

HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; HLA-DRB2; HLA-DRB3; HLA-DRB4;HLA-DRw12

HLA-Dw12; HLA-E; HLA-F; HLA-G; HLA-G2.2; HLA-H; HLAC;IGHA1

IGHA2; IGHD; IGHE; IGHG1; IGHG2; IGHG3; IGHG4;IGHM

IGHV4-31; IGKC; IGKV1-5; IGKV2-24; IGL@; IGLC1; IGLC3;IGLL1

IGLV2-14; IGLV3-21; IGLV3-25; IGLV4-3; MICA; MICB; MR1;SIRPA

SIRPB1; SIRPG; SNC73; TAPBP; TAPBPL; TRBC1; TRBV19;TRBV21-1

TRBV3-1; TRBV5-4; TRBV7-2; micB;

Notes and References

1. Cresswell P, Pamer E . Mechanisms of MHC class I--restricted antigen processing . Annu. Rev. Immunol. . 16 . 1 . 323–358 . 1998 . 9597133 . 10.1146/annurev.immunol.16.1.323 .
2. Ono SJ, Radosevich M . Novel mechanisms of class II major histocompatibility complex gene regulation . Immunol Res . 27 . 1 . 85–106 . 2003 . 12637770 . 10.1385/IR:27:1:85. 5872652 .