Imiclopazine Explained
| Inn: | Imiclopazine |
| Iupac Name: | 1-[2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl]-3-methylimidazolidin-2-one |
| Tradename: | Ponsital[1] [2] |
| Atc Prefix: | N05 |
| Atc Suffix: | AB |
| Legal Br: | C1 |
| Legal Br Comment: | [3] |
| Cas Number: | 7224-08-0 |
| Pubchem: | 23896 |
| Chemspiderid: | 22341 |
| Unii: | WGL8B3MDAS |
| Chebi: | 135784 |
| Chembl: | 2105043 |
| C: | 25 |
| H: | 32 |
| Cl: | 1 |
| N: | 5 |
| O: | 1 |
| S: | 1 |
| Smiles: | CN1CCN(C1=O)CCN2CCN(CC2)CCCN3C4=CC=CC=C4SC5=C3C=C(C=C5)Cl |
| Stdinchi: | 1S/C25H32ClN5OS/c1-27-11-17-30(25(27)32)18-16-29-14-12-28(13-15-29)9-4-10-31-21-5-2-3-6-23(21)33-24-8-7-20(26)19-22(24)31/h2-3,5-8,19H,4,9-18H2,1H3 |
| Stdinchikey: | OCDYNPAUUKDNOR-UHFFFAOYSA-N |
Imiclopazine is an antipsychotic drug of the phenothiazines class, developed in the 1960s by the pharmaceutical company Asta-Werke under the brand name Ponsital. It demonstrated strong sedative and antiemetic properties.[4] [5]
It was initially researched for the treatment of schizophrenia and had favorable clinical trials,[6] but ultimately was never brought to market.[4]
Notes and References
- Book: Milne GW . Drugs: Synonyms and Properties . 2002-02-01 . John Wiley & Sons . 978-0-566-08491-1 . 2nd . 427 . en.
- News: 1986-11-05 . Substâncias e remédios sob controle . pt-br . Substances and drugs under control . 14 . . live . 2023-08-08 . https://web.archive.org/web/20230808230340/https://memoria.bn.br/pdf/030015/per030015_1986_00211.pdf . 2023-08-08.
- Web site: Anvisa . Brazilian Health Regulatory Agency . 2023-03-31 . RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial . Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control. live . https://web.archive.org/web/20230803143925/https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 . 2023-08-03 . 2023-08-03 . . pt-BR . 2023-04-04.
- Web site: Imiclopazine . 2023-08-09 . NCATS Inxight Drugs . National Center for Advancing Translational Sciences (NCATS) . en.
- Nurowska K, Welbel L . [Treatment of schizophrenia with imiclopazine, pimozide, imagotan and trifluorperidol. Comparative study] . Psychiatria Polska . 7 . 1 . 57–63 . 1973 . 4146043 .
- Eckmann F, Immich H, Schäpperle O . 1968 . Langzeitbehandlung mit PONSITAL bei chronisch psychisch Kranken . International Pharmacopsychiatry . de . 1 . 1 . 80–85 . 10.1159/000467919 . 0020-8272.
