Ilse Kaschube (later Zeisler, born 25 June 1953 in Altentreptow, Bezirk Neubrandenburg) is an East German canoe sprinter who competed in the early 1970s. She won a silver medal in the K-2 500 m event at the 1972 Summer Olympics in Munich.
Kaschube also won two gold medals at the ICF Canoe Sprint World Championships with one in the K-2 500 m event (1973) and one in the K-4 500 m event (1974).