| State: | IL |
| Type: | IL |
| Maint: | IDOT |
| Route: | 149 |
| Map Custom: | yes |
| Map Notes: | IL 149 highlighted in red |
| Length Mi: | 45.92 |
| Length Round: | 2 |
| Length Ref: | [1] |
| Direction B: | East |
| Direction A: | West |
| Terminus A: | in Gorham |
| Junction: | in DeSoto in West Frankfort |
| Terminus B: | in Thompsonville |
| Counties: | Jackson, Williamson, Franklin |
| Established: | 1926[2] |
| Previous Route: | 148 |
| Previous Type: | IL |
| Next Route: | 150 |
| Next Type: | US |
Illinois Route 149 is an east - west state road in southern Illinois. It runs from Illinois Route 3 near Grimsby east to Illinois Route 34 in Thompsonville. This is a distance of 45.92miles.
Illinois 149 runs east - west through downtown Murphysboro and to the north of Carbondale. It also runs to the north of Herrin. West of Carbondale, Illinois 149 overlaps Illinois Routes 13 and 127. Through West Frankfort, Illinois 149 doubles as "Main Street."
SBI Route 149 originally ran from Hurst to Thompsonville. On April 1, 1963, IL 149 was extended 21miles east over IL 144.[3]