CD79B explained

CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene.^[1]

It is associated with agammaglobulinemia-6.

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.

See also

• Cluster of differentiation

Further reading

• Reth M . Antigen receptors on B lymphocytes . Annu. Rev. Immunol. . 10 . 97–121 . 1992 . 1591006 . 10.1146/annurev.iy.10.040192.000525 .
• Müller B, Cooper L, Terhorst C . Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29 . Eur. J. Immunol. . 22 . 6 . 1621–5 . 1992 . 1534761 . 10.1002/eji.1830220641 . 23910309 .
• Lankester AC, van Schijndel GM, Cordell JL . CD5 is associated with the human B cell antigen receptor complex . Eur. J. Immunol. . 24 . 4 . 812–6 . 1994 . 7512031 . 10.1002/eji.1830240406 . 25093082 . etal.
• Vasile S, Coligan JE, Yoshida M, Seon BK . Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex . Mol. Immunol. . 31 . 6 . 419–27 . 1994 . 7514267 . 10.1016/0161-5890(94)90061-2 .
• Brown VK, Ogle EW, Burkhardt AL . Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45 . J. Biol. Chem. . 269 . 25 . 17238–44 . 1994 . 10.1016/S0021-9258(17)32545-0 . 7516335 . etal. free .
• Rowley RB, Burkhardt AL, Chao HG . Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation . J. Biol. Chem. . 270 . 19 . 11590–4 . 1995 . 7538118 . 10.1074/jbc.270.19.11590 . etal. free .
• Pani G, Kozlowski M, Cambier JC . Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling . J. Exp. Med. . 181 . 6 . 2077–84 . 1995 . 7539038 . 10.1084/jem.181.6.2077 . 2192043 . etal.
• Müller B, Cooper L, Terhorst C . Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29) . Immunol. Lett. . 44 . 2–3 . 97–103 . 1995 . 7541024 . 10.1016/0165-2478(94)00199-2 .
• Saouaf SJ, Kut SA, Fargnoli J . Reconstitution of the B cell antigen receptor signaling components in COS cells . J. Biol. Chem. . 270 . 45 . 27072–8 . 1995 . 7592958 . 10.1074/jbc.270.45.27072 . etal. free .
• Hashimoto S, Chiorazzi N, Gregersen PK . Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells . Mol. Immunol. . 32 . 9 . 651–9 . 1995 . 7643857 . 10.1016/0161-5890(95)00023-8 . free .
• Hashimoto S, Chiorazzi N, Gregersen PK . The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism . Immunogenetics . 40 . 2 . 145–9 . 1994 . 7913081 . 10.1007/BF00188178 . 6966566 .
• Gold MR, Chiu R, Ingham RJ . Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes . J. Immunol. . 153 . 6 . 2369–80 . 1994 . 10.4049/jimmunol.153.6.2369 . 8077654 . 22158525 . etal.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Hashimoto S, Gregersen PK, Chiorazzi N . The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes . J. Immunol. . 150 . 2 . 491–8 . 1993 . 10.4049/jimmunol.150.2.491 . 8419481 . 36149482 . free .
• Wood WJ, Thompson AA, Korenberg J . Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB) . Genomics . 16 . 1 . 187–92 . 1993 . 8486355 . 10.1006/geno.1993.1157 . etal.
• Thompson AA, Wood WJ, Gilly MJ . The promoter and 5' flanking sequences controlling human B29 gene expression . Blood . 87 . 2 . 666–73 . 1996 . 8555489 . 10.1182/blood.V87.2.666.bloodjournal872666. etal. free .
• Astsaturov IA, Matutes E, Morilla R . Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia . Leukemia . 10 . 5 . 769–73 . 1996 . 8656670 . etal.
• Koyama M, Nakamura T, Higashihara M . The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing . Immunol. Lett. . 47 . 3 . 151–6 . 1996 . 8747711 . 10.1016/0165-2478(95)00071-X . etal.
• Carter RH, Doody GM, Bolen JB, Fearon DT . Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex . J. Immunol. . 158 . 7 . 3062–9 . 1997 . 10.4049/jimmunol.158.7.3062 . 9120258 . 20717278 . free .

External links

• • • PDBe-KB provides an overview of all the structure information available in the PDB for Human B-cell antigen receptor complex-associated protein beta chain (CD79B)

Notes and References

1. Web site: Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta.