Idrocilamide Explained

Idrocilamide (trade names Talval, Srilane, Relaxnova, Brolitène^[1]) is a medication with skeletal muscle relaxant^[2] and anti-inflammatory actions^[3] used as a topical cream to treat lumbago and other kinds of muscular pain;^[4] it is available on prescription or over-the-counter in France and various other countries.

Interactions

Idrocilamide has been reported to be a potent inhibitor of the metabolism of caffeine.^{[5] [6]}

Notes and References

1. Drugs.com:
2. Bouron A, Rivet M, Nasri-Sebdani M, Guillemain J, Durbin P, Guerrier D, Raymond G . 1990 . The direct depressant effect of LCB29 (idrocilamide) on mechanical tension of rat soleus muscle fibers . . 68 . 12 . 1503–1509 . 10.1139/y90-228 . 2085796.
3. Bannwarth B, Le Huec JC, Vinçon G, Labat L, Demotes-Mainard F, Rivaille F, Le Rebeller A . 1993 . [Tissue and systemic diffusion of idrocilamide after cutaneous administration] . French . . 60 . 12 . 932–6 . 8012322 .
4. Stehman M, Lehert P . 1990 . Clinical double-blind study with idrocilamide ointment in the treatment of acute lumbago . . 13 . 1 . 29–32 . 2140002.
5. Carrillo JA, Benitez J . 2000 . Clinically significant pharmacokinetic interactions between dietary caffeine and medications . . 39 . 2 . 127–53 . 10.2165/00003088-200039020-00004 . 10976659.
6. Brazier JL, Descotes J, Lery N, Ollagnier M, Evreux JC . 1980 . Inhibition by idrocilamide of the disposition of caffeine . . 17 . 1 . 37–43 . 10.1007/bf00561675 . 7371698.