ICMT explained

Protein-S-isoprenylcysteine O-methyltransferase is an enzyme that in humans is encoded by the ICMT gene.^{[1] [2] [3]}

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.

Further reading

• Choy E . Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi . Cell . 98 . 1 . 69–80 . 1999 . 10412982 . 10.1016/S0092-8674(00)80607-8 . vanc. Chiu VK . Silletti J . 3 . Feoktistov . M . Morimoto . T . Michaelson . D . Ivanov . I . Philips . M . 1018802 . free .
• Lin X . Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1 . Nat. Neurosci. . 3 . 2 . 157–63 . 2000 . 10649571 . 10.1038/72101 . vanc. Antalffy B . Kang D . 3 . Kang . Dongcheul . Orr . Harry T. . 2800058 .
• Van Dessel GA, De Busser HM, Lagrou AR . Prenylcysteine carboxymethyltransferase type III activity is decreased in retinoic acid-treated SH-SY5Y neuroblastoma cells . Int. J. Biochem. Cell Biol. . 34 . 5 . 477–86 . 2002 . 11906819 . 10.1016/S1357-2725(01)00151-0 .
• Ahmad M . Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells . Arterioscler. Thromb. Vasc. Biol. . 22 . 5 . 759–64 . 2002 . 12006387 . 10.1161/01.ATV.0000015884.61894.DC . vanc. Zhang Y . Zhang Y . 3 . Papharalambus . C . Alexander . RW . free.
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Kramer K . Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis . Mol. Biol. Cell . 14 . 3 . 848–57 . 2004 . 12631708 . 10.1091/mbc.E02-07-0390 . 151564 . vanc. Harrington EO . Lu Q . 3 . Bellas . R . Newton . J . Sheahan . KL . Rounds . S .
• Winter-Vann AM . Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate . Proc. Natl. Acad. Sci. U.S.A. . 100 . 11 . 6529–34 . 2003 . 12750467 . 10.1073/pnas.1135239100 . 164480 . vanc. Kamen BA . Bergo MO . 3 . Young . SG . Melnyk . S . James . SJ . Casey . PJ . 2003PNAS..100.6529W . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Bergo MO . Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf . J. Clin. Invest. . 113 . 4 . 539–50 . 2004 . 14966563 . 10.1172/JCI18829 . 338259 . vanc. Gavino BJ . Hong C . 3 . Beigneux . AP . McMahon . M . Casey . PJ . Young . SG .
• Brandenberger R . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . vanc. Wei H . Zhang S . 3 . Lei . Shirley . Murage . Jaji . Fisk . Gregory J . Li . Yan . Xu . Chunhui . Fang . Rixun . 27764390 .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Lu Q . Inhibition of ICMT induces endothelial cell apoptosis through GRP94 . Am. J. Respir. Cell Mol. Biol. . 37 . 1 . 20–30 . 2007 . 17347446 . 10.1165/rcmb.2006-0301SM . 1899353 . vanc. Harrington EO . Newton J . 3 . Jankowich . M. . Rounds . S. .

Notes and References

1. Dai Q, Choy E, Chiu V, Romano J, Slivka SR, Steitz SA, Michaelis S, Philips MR . Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum . J Biol Chem . 273 . 24 . 15030–4 . Jul 1998 . 9614111 . 10.1074/jbc.273.24.15030 . free .
2. Desrosiers RR, Nguyen QT, Beliveau R . The carboxyl methyltransferase modifying G proteins is a metalloenzyme . Biochem Biophys Res Commun . 261 . 3 . 790–7 . Sep 1999 . 10441503 . 10.1006/bbrc.1999.0936 .
3. Web site: Entrez Gene: ICMT isoprenylcysteine carboxyl methyltransferase.