I-cell explained

Fritz Heinrich Jakob Lewy, a German-American neurologist, first identified and described inclusions in the brain cells of patients with Parkinson's disease and published his findings in the Lewandowsky's Handbook of Neurology in 1912.^[1] I-cells also called inclusion cells are abnormal fibroblasts having a large number of dark inclusions in the cytoplasm of the cell (mainly in the central area). They are metabolically inactive structures of a cell and are not enclosed by a membrane.^[2] The inclusions are of various fats, proteins, carbohydrates, pigments, excretory products, crystals,^[3] and other insolubles. They are found in the cytoplasm of a cell in both prokaryotes and eukaryotes.^[4] They are seen in Mucolipidosis II,^[5] and Mucolipidosis III, also called inclusion-cell or I-cell disease where lysosomal enzyme transport and storage is affected.^[6]

Notes and References

1. Engelhardt. Eliasz. October 2017. Lafora and Trétiakoff: the naming of the inclusion bodies discovered by Lewy. Arquivos de Neuro-Psiquiatria. en. 75. 10 . 751–753. 10.1590/0004-282X20170116. 29166468 . 0004-282X. free.
2. Web site: Lakna. 2018-11-03. What is the Difference Between Cell Organelles and Cell Inclusions. 2021-12-09. Pediaa.Com. en-US.
3. Leliaert. Frederik. Coppejans. Eric. March 2004. Crystalline cell inclusions: a new diagnostic character in the Cladophorophyceae (Chlorophyta). Phycologia. en. 43. 2. 189–203. 10.2216/i0031-8884-43-2-189.1. 86155723 . 0031-8884.
4. Web site: inclusion body biology Britannica. 2021-12-09. britannica.com. en.
5. Book: al.]. consultants Daniel Albert ... [et|title=Dorland's illustrated medical dictionary.|date=2012|publisher=Saunders/Elsevier|location=Philadelphia, PA|isbn=978-1-4160-6257-8|pages=319 and 928|edition=32nd].
6. Web site: Mucolipidoses Fact Sheet National Institute of Neurological Disorders and Stroke. 2021-12-09. ninds.nih.gov.