ITPK1 explained
Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.[1] [2] [3]
It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis.[4] [5]
Further reading
- Wilson MP, Sun Y, Cao L, Majerus PW . Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2. . J. Biol. Chem. . 276 . 44 . 40998–1004 . 2001 . 11533064 . 10.1074/jbc.M106605200 . free .
- Ho MW, Yang X, Carew MA, etal . Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase. . Curr. Biol. . 12 . 6 . 477–82 . 2002 . 11909533 . 10.1016/S0960-9822(02)00713-3 . free .
- Sun Y, Wilson MP, Majerus PW . Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1. . J. Biol. Chem. . 277 . 48 . 45759–64 . 2003 . 12324474 . 10.1074/jbc.M208709200 . free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Sun Y, Mochizuki Y, Majerus PW . Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis. . J. Biol. Chem. . 278 . 44 . 43645–53 . 2003 . 12925536 . 10.1074/jbc.M300674200 . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Qian X, Mitchell J, Wei SJ, etal . The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase. . Biochem. J. . 389 . Pt 2 . 389–95 . 2005 . 15762844 . 10.1042/BJ20050297 . 1175116 .
- Miller GJ, Wilson MP, Majerus PW, Hurley JH . Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase. . Mol. Cell . 18 . 2 . 201–12 . 2005 . 15837423 . 10.1016/j.molcel.2005.03.016 . free .
- Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
Notes and References
- Wilson MP, Majerus PW . Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme . J Biol Chem . 271 . 20 . 11904–10 . Aug 1996 . 8662638 . 10.1074/jbc.271.20.11904 . free .
- Yang X, Shears SB . Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase . Biochem J . 351 . 3. 551–5 . Jan 2001 . 11042108 . 1221393 . 10.1042/0264-6021:3510551.
- Web site: Entrez Gene: ITPK1 inositol 1,3,4-triphosphate 5/6 kinase.
- Saiardi A, Cockcroft S . Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels . Sci Signal . 1 . 4 . pe5 . 2008 . 18272466 . 10.1126/stke.14pe5 . 36710246 .
- Chamberlain PP, Qian X, Stiles AR, Cho J, Jones DH, Lesley SA, Grabau EA, Shears SB, Spraggon G . Integration of inositol phosphate signaling pathways via human ITPK1 . J. Biol. Chem. . 282 . 38 . 28117–25 . September 2007 . 17616525 . 2244811 . 10.1074/jbc.M703121200 . free .