ITM2A explained

Integral membrane protein 2A is a protein that in humans is encoded by the ITM2A gene.^{[1] [2] [3] [4]}

Function

The protein encoded by this gene is involved in osteo- and chondrogenic cellular differentiation (the cells which are responsible for the development of bone and cartilage respectively).

ITM2A is also involved in activation of T-cells in the immune system^[5] and in myocyte differentiation.^[6]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Prashar Y, Weissman SM . Analysis of differential gene expression by display of 3' end restriction fragments of cDNAs . Proc. Natl. Acad. Sci. U.S.A. . 93 . 2 . 659–63 . 1996 . 8570611 . 10.1073/pnas.93.2.659 . 40108 . 1996PNAS...93..659P . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Mao M, Fu G, Wu JS, etal . Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning . Proc. Natl. Acad. Sci. U.S.A. . 95 . 14 . 8175–80 . 1998 . 9653160 . 10.1073/pnas.95.14.8175 . 20949 . 1998PNAS...95.8175M . free .
• Kirchner J, Bevan MJ . Itm2a Is Induced during Thymocyte Selection and T Cell Activation and Causes Downregulation of Cd8 When Overexpressed in Cd4+Cd8+ Double Positive Thymocytes . J. Exp. Med. . 190 . 2 . 217–28 . 1999 . 10432285 . 10.1084/jem.190.2.217 . 2195576 .
• Zhang QH, Ye M, Wu XY, etal . Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E, etal . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ross MT, Grafham DV, Coffey AJ, etal . The DNA sequence of the human X chromosome . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286 . 2005Natur.434..325R .

Notes and References

1. Pittois K, Wauters J, Bossuyt P, Deleersnijder W, Merregaert J . Genomic organization and chromosomal localization of the Itm2a gene . Mamm Genome . 10 . 1 . 54–6 . Mar 1999 . 9892734 . 10.1007/s003359900942 . 24117211 .
2. Deleersnijder W, Hong G, Cortvrindt R, Poirier C, Tylzanowski P, Pittois K, Van Marck E, Merregaert J . Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins . J Biol Chem . 271 . 32 . 19475–82 . Sep 1996 . 8702637 . 10.1074/jbc.271.32.19475 . free .
3. Web site: Entrez Gene: ITM2A integral membrane protein 2A.
4. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z . Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning . Proc. Natl. Acad. Sci. U.S.A. . 95 . 14 . 8175–80 . July 1998 . 9653160 . 20949 . 10.1073/pnas.95.14.8175. 1998PNAS...95.8175M . free .
5. Kirchner J, Bevan MJ . Itm2a Is Induced during Thymocyte Selection and T Cell Activation and Causes Downregulation of Cd8 When Overexpressed in Cd4+Cd8+ Double Positive Thymocytes . J. Exp. Med. . 190 . 2 . 217–28 . July 1999 . 10432285 . 2195576 . 10.1084/jem.190.2.217 .
6. Van den Plas D, Merregaert J . Constitutive overexpression of the integral membrane protein Itm2A enhances myogenic differentiation of C2C12 cells . Cell Biol. Int. . 28 . 3 . 199–207 . 2004 . 14984746 . 10.1016/j.cellbi.2003.11.019 . 28123188 .