ITIH4 explained

Inter-alpha-trypsin inhibitor heavy chain H4 is a protein that in humans is encoded by the ITIH4 gene.^{[1] [2] [3]}

See also

• Inter-alpha-trypsin inhibitor
• ITIH1
• ITIH2
• ITIH3

Further reading

• Choi-Miura NH, Sano Y, Oda E, etal . Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma. . J. Biochem. . 117 . 2 . 400–7 . 1995 . 7541790 . 10.1093/jb/117.2.400 .
• Tobe T, Saguchi K, Hashimoto K, etal . Mapping of human inter-alpha-trypsin inhibitor family heavy chain-related protein gene (ITIHL1) to human chromosome 3p21→p14. . Cytogenet. Cell Genet. . 71 . 3 . 296–8 . 1995 . 7587397 . 10.1159/000134130 .
• Saguchi K, Tobe T, Hashimoto K, etal . Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein. . J. Biochem. . 117 . 1 . 14–8 . 1995 . 7775381 . 10.1093/oxfordjournals.jbchem.a124701.
• Saguchi K, Tobe T, Hashimoto K, etal . Isolation and characterization of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1). . J. Biochem. . 119 . 5 . 898–905 . 1997 . 8797089 . 10.1093/oxfordjournals.jbchem.a021327.
• Jean L, Smih F, Olivier E, etal . Comparative assignments of the genes of the inter-alpha-inhibitor family in human and mouse: ITIH4 is close to ITIH1 and ITIH3, on HSA 3 and MMU 14. . Genomics . 41 . 1 . 139–40 . 1997 . 9126497 . 10.1006/geno.1997.4612 .
• Diarra-Mehrpour M, Sarafan N, Bourguignon J, etal . Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage. . J. Biol. Chem. . 273 . 41 . 26809–19 . 1998 . 9756925 . 10.1074/jbc.273.41.26809 . free .
• Tozaki T, Choi-Miura NH, Taniyama M, etal . SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene by a fluorescence-adapted SSCP method. . BMC Med. Genet. . 3. 6 . 2003 . 12147176 . 10.1186/1471-2350-3-6 . 117798 . free .
• Zhang H, Li XJ, Martin DB, Aebersold R . Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. . Nat. Biotechnol. . 21 . 6 . 660–6 . 2003 . 12754519 . 10.1038/nbt827 . 581283 .
• Fujita Y, Ezura Y, Emi M, etal . Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene. . J. Hum. Genet. . 49 . 1 . 24–8 . 2004 . 14661079 . 10.1007/s10038-003-0101-8 . free .
• Anderson NL, Polanski M, Pieper R, etal . The human plasma proteome: a nonredundant list developed by combination of four separate sources. . Mol. Cell. Proteomics . 3 . 4 . 311–26 . 2004 . 14718574 . 10.1074/mcp.M300127-MCP200 . free .
• Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR . Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. . Proteomics . 4 . 2 . 454–65 . 2004 . 14760718 . 10.1002/pmic.200300556 . 29261009 .
• Kroczynska B, King-Simmons L, Alloza L, etal . BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4. . Biochem. Biophys. Res. Commun. . 338 . 3 . 1467–77 . 2006 . 16271702 . 10.1016/j.bbrc.2005.10.101 .
• Liu T, Qian WJ, Gritsenko MA, etal . Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. . J. Proteome Res. . 4 . 6 . 2070–80 . 2006 . 16335952 . 10.1021/pr0502065 . 1850943 .

Notes and References

1. Soury E, Olivier E, Daveau M, Hiron M, Claeyssens S, Risler JL, Salier JP . The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human . Biochem Biophys Res Commun . 243 . 2 . 522–30 . Mar 1998 . 9480842 . 10.1006/bbrc.1998.8128 .
2. Nishimura H, Kakizaki I, Muta T, Sasaki N, Pu PX, Yamashita T, Nagasawa S . cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein . FEBS Lett . 357 . 2 . 207–11 . Feb 1995 . 7805892 . 10.1016/0014-5793(94)01364-7 . free . 1995FEBSL.357..207H .
3. Web site: Entrez Gene: ITIH4 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein).