ITIH3 explained

Inter-alpha-trypsin inhibitor heavy chain H3 is a protein that in humans is encoded by the ITIH3 gene.^{[1] [2] [3]}

See also

• Inter-alpha-trypsin inhibitor
• ITIH1
• ITIH2
• ITIH4

Further reading

• Salier JP, Simon D, Rouet P, etal . Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. . Genomics . 14 . 1 . 83–8 . 1992 . 1385302 . 10.1016/S0888-7543(05)80287-3 .
• Enghild JJ, Salvesen G, Hefta SA, etal . Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor. . J. Biol. Chem. . 266 . 2 . 747–51 . 1991 . 10.1016/S0021-9258(17)35235-3 . 1898736 . free .
• Salier JP, Diarra-Mehrpour M, Sesboue R, etal . Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI. . Proc. Natl. Acad. Sci. U.S.A. . 84 . 23 . 8272–6 . 1988 . 2446322 . 10.1073/pnas.84.23.8272 . 299524 . free .
• Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G . Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. . J. Biol. Chem. . 264 . 27 . 15975–81 . 1989 . 10.1016/S0021-9258(18)71575-5 . 2476436 . free .
• Diarra-Mehrpour M, Bourguignon J, Sarafan N, etal . Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes. . Biochim. Biophys. Acta . 1219 . 2 . 551–4 . 1994 . 7522574 . 10.1016/0167-4781(94)90087-6.
• Bourguignon J, Diarra-Mehrpour M, Thiberville L, etal . Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence. . Eur. J. Biochem. . 212 . 3 . 771–6 . 1993 . 7681778 . 10.1111/j.1432-1033.1993.tb17717.x .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Blom AM, Thuveson M, Fries E . Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells . Biochem. J. . 328 . 1. 185–91 . 1998 . 9359851 . 10.1042/bj3280185. 1218904 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Diarra-Mehrpour M, Sarafan N, Bourguignon J, etal . Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage . J. Biol. Chem. . 273 . 41 . 26809–19 . 1998 . 9756925 . 10.1074/jbc.273.41.26809 . free .
• Thuveson M, Fries E . Intracellular proteolytic processing of the heavy chain of rat pre-alpha-inhibitor. The COOH-terminal propeptide is required for coupling to bikunin . J. Biol. Chem. . 274 . 10 . 6741–6 . 1999 . 10037773 . 10.1074/jbc.274.10.6741 . free .
• Bourguignon J, Borghi H, Sesboüé R, etal . Immunohistochemical distribution of inter-alpha-trypsin inhibitor chains in normal and malignant human lung tissue . J. Histochem. Cytochem. . 47 . 12 . 1625–32 . 1999 . 10567446 . 10.1177/002215549904701214. free .
• Thuveson M, Fries E . The low pH in trans-Golgi triggers autocatalytic cleavage of pre-alpha -inhibitor heavy chain precursor . J. Biol. Chem. . 275 . 40 . 30996–1000 . 2000 . 10893227 . 10.1074/jbc.M002399200 . free .
• Kato M, Seki N, Sugano S, etal . Identification of sonic hedgehog-responsive genes using cDNA microarray . Biochem. Biophys. Res. Commun. . 289 . 2 . 472–8 . 2002 . 11716497 . 10.1006/bbrc.2001.5976 .
• Paris S, Sesboüé R, Delpech B, etal . Inhibition of tumor growth and metastatic spreading by overexpression of inter-alpha-trypsin inhibitor family chains . Int. J. Cancer . 97 . 5 . 615–20 . 2002 . 11807786 . 10.1002/ijc.10120 . 41750371 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .

Notes and References

1. Diarra-Mehrpour M, Bourguignon J, Sesboue R, Mattei MG, Passage E, Salier JP, Martin JP . Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes . Eur J Biochem . 179 . 1 . 147–54 . Apr 1989 . 2465147 . 10.1111/j.1432-1033.1989.tb14532.x .
2. Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP . The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair? . FEBS Lett . 446 . 1 . 6–8 . May 1999 . 10100603 . 10.1016/S0014-5793(99)00173-8 . 84807160 .
3. Web site: Entrez Gene: ITIH3 inter-alpha (globulin) inhibitor H3.