ITIH1 explained

Inter-alpha-trypsin inhibitor heavy chain H1 is a protein that in humans is encoded by the ITIH1 gene.^{[1] [2] [3]}

See also

• Inter-alpha-trypsin inhibitor
• ITIH2
• ITIH3
• ITIH4

Further reading

• Diarra-Mehrpour M, Bourguignon J, Bost F, etal . Human inter-alpha-trypsin inhibitor: full-length cDNA sequence of the heavy chain H1 . Biochim. Biophys. Acta . 1132 . 1 . 114–8 . 1992 . 1380832 . 10.1016/0167-4781(92)90065-8.
• Malki N, Balduyck M, Maes P, etal . The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A . Biol. Chem. Hoppe-Seyler . 373 . 10 . 1009–18 . 1992 . 1384548 . 10.1515/bchm3.1992.373.2.1009 .
• Salier JP, Diarra-Mehrpour M, Sesboue R, etal . Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI . Proc. Natl. Acad. Sci. U.S.A. . 84 . 23 . 8272–6 . 1988 . 2446322 . 10.1073/pnas.84.23.8272 . 299524 . free .
• Diarra-Mehrpour M, Bourguignon J, Sesboüé R, etal . Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes . Eur. J. Biochem. . 179 . 1 . 147–54 . 1989 . 2465147 . 10.1111/j.1432-1033.1989.tb14532.x .
• Gebhard W, Schreitmüller T, Hochstrasser K, Wachter E . Two out of the three kinds of subunits of inter-alpha-trypsin inhibitor are structurally related . Eur. J. Biochem. . 181 . 3 . 571–6 . 1989 . 2471637 . 10.1111/j.1432-1033.1989.tb14762.x . free .
• Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G . Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan . J. Biol. Chem. . 264 . 27 . 15975–81 . 1989 . 10.1016/S0021-9258(18)71575-5 . 2476436 . free .
• Schreitmüller T, Hochstrasser K, Reisinger PW, etal . cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins . Biol. Chem. Hoppe-Seyler . 368 . 8 . 963–70 . 1987 . 3663330 . 10.1515/bchm3.1987.368.2.963 .
• Huang L, Yoneda M, Kimata K . A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor . J. Biol. Chem. . 268 . 35 . 26725–30 . 1994 . 10.1016/S0021-9258(19)74373-7 . 7504674 . free .
• Bost F, Bourguignon J, Martin JP, etal . Isolation and characterization of the human inter-alpha-trypsin inhibitor heavy-chain H1 gene . Eur. J. Biochem. . 218 . 2 . 283–91 . 1994 . 7505744 . 10.1111/j.1432-1033.1993.tb18376.x . free .
• Morelle W, Capon C, Balduyck M, etal . Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor . Eur. J. Biochem. . 221 . 2 . 881–8 . 1994 . 7513643 . 10.1111/j.1432-1033.1994.tb18803.x .
• Diarra-Mehrpour M, Bourguignon J, Sarafan N, etal . Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes . Biochim. Biophys. Acta . 1219 . 2 . 551–4 . 1994 . 7522574 . 10.1016/0167-4781(94)90087-6.
• Ding M, Umetsu K, Yuasa I, etal . Molecular basis of inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) polymorphism . Hum. Genet. . 95 . 4 . 435–6 . 1995 . 7535743 . 10.1007/BF00208970 . 26535335 .
• Zhao M, Yoneda M, Ohashi Y, etal . Evidence for the covalent binding of SHAP, heavy chains of inter-alpha-trypsin inhibitor, to hyaluronan . J. Biol. Chem. . 270 . 44 . 26657–63 . 1995 . 7592891 . 10.1074/jbc.270.44.26657 . free .
• Bourguignon J, Diarra-Mehrpour M, Thiberville L, etal . Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence . Eur. J. Biochem. . 212 . 3 . 771–6 . 1993 . 7681778 . 10.1111/j.1432-1033.1993.tb17717.x .
• Olsen EH, Rahbek-Nielsen H, Thogersen IB, etal . Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2 . Biochemistry . 37 . 1 . 408–16 . 1998 . 9425062 . 10.1021/bi971137d .
• Flahaut C, Capon C, Balduyck M, etal . Glycosylation pattern of human inter-alpha-inhibitor heavy chains . Biochem. J. . 333 (Pt 3) . Pt 3. 749–56 . 1998 . 9677337 . 10.1042/bj3330749. 1219641 .
• Flahaut C, Mizon C, Aumercier-Maes P, etal . Disulphide bonds assignment in the inter-alpha-inhibitor heavy chains--structural and functional implications . Eur. J. Biochem. . 255 . 1 . 107–15 . 1998 . 9692908 . 10.1046/j.1432-1327.1998.2550107.x . free .
• Diarra-Mehrpour M, Sarafan N, Bourguignon J, etal . Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage . J. Biol. Chem. . 273 . 41 . 26809–19 . 1998 . 9756925 . 10.1074/jbc.273.41.26809 . free .

Notes and References

1. Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG . Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily . Genomics . 14 . 1 . 83–8 . Dec 1992 . 1385302 . 10.1016/S0888-7543(05)80287-3 .
2. Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP . The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair? . FEBS Lett . 446 . 1 . 6–8 . May 1999 . 10100603 . 10.1016/S0014-5793(99)00173-8 . 84807160 .
3. Web site: Entrez Gene: ITIH1 inter-alpha (globulin) inhibitor H1.