Integrin beta 5 explained

Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.^{[1] [2]}

Interactions

Integrin, beta 5 has been shown to interact with PTK2,^[3] Annexin A5^[4] and PAK4.^[5]

Functions

ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It also plays a potential role in intercellular communication during tumor progression and metastasis.^[6]

Clinical significance

Research

Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones.^[7]

Further reading

• Evans JP . Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization. . BioEssays . 23 . 7 . 628–39 . 2001 . 11462216 . 10.1002/bies.1088 . 23712246 .
• Smith JW, Vestal DJ, Irwin SV, etal . Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin. . J. Biol. Chem. . 265 . 19 . 11008–13 . 1990 . 10.1016/S0021-9258(19)38549-7 . 1694173 . free .
• Adams JC, Watt FM . Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes. . J. Cell Biol. . 115 . 3 . 829–41 . 1991 . 1918165 . 10.1083/jcb.115.3.829 . 2289188 .
• Ramaswamy H, Hemler ME . Cloning, primary structure and properties of a novel human integrin beta subunit. . EMBO J. . 9 . 5 . 1561–8 . 1990 . 2328726 . 10.1002/j.1460-2075.1990.tb08275.x. 551850 .
• Suzuki S, Huang ZS, Tanihara H . Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit. . Proc. Natl. Acad. Sci. U.S.A. . 87 . 14 . 5354–8 . 1990 . 2371275 . 10.1073/pnas.87.14.5354 . 54322 . 1990PNAS...87.5354S . free .
• Hu DD, Lin EC, Kovach NL, etal . A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5. . J. Biol. Chem. . 270 . 44 . 26232–8 . 1995 . 7592829 . 10.1074/jbc.270.44.26232 . free .
• Vogel BE, Lee SJ, Hildebrand A, etal . A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin. . J. Cell Biol. . 121 . 2 . 461–8 . 1993 . 7682219 . 10.1083/jcb.121.2.461 . 2200091 .
• Pasqualini R, Bodorova J, Ye S, Hemler ME . A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies. . J. Cell Sci. . 105 . 1. 101–11 . 1993 . 10.1242/jcs.105.1.101 . 7689573 .
• Lafrenie RM, Wahl LM, Epstein JS, etal . HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes. . Journal of Immunology . 157 . 3 . 974–7 . 1996 . 10.4049/jimmunol.157.3.974 . 8757599 . free .
• Rabb H, Barroso-Vicens E, Adams R, etal . Alpha-V/beta-3 and alpha-V/beta-5 integrin distribution in neoplastic kidney. . Am. J. Nephrol. . 16 . 5 . 402–8 . 1997 . 8886177 . 10.1159/000169032 .
• Liliental J, Chang DD . Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit. . J. Biol. Chem. . 273 . 4 . 2379–83 . 1998 . 9442085 . 10.1074/jbc.273.4.2379 . free .
• Memmo LM, McKeown-Longo P . The alphavbeta5 integrin functions as an endocytic receptor for vitronectin. . J. Cell Sci. . 111 . 4. 425–33 . 1998 . 10.1242/jcs.111.4.425 . 9443892 .
• Zhang H, Tan SM, Lu J . cDNA cloning reveals two mouse beta5 integrin transcripts distinct in cytoplasmic domains as a result of alternative splicing. . Biochem. J. . 331 . 2. 631–7 . 1998 . 9531507 . 10.1042/bj3310631. 1219398 .
• Barillari G, Sgadari C, Palladino C, etal . Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin. . Journal of Immunology . 163 . 4 . 1929–35 . 1999 . 10.4049/jimmunol.163.4.1929 . 10438928 . free .
• Carriero MV, Del Vecchio S, Capozzoli M, etal . Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer. . Cancer Res. . 59 . 20 . 5307–14 . 1999 . 10537314 .
• Tang S, Gao Y, Ware JA . Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein. . J. Cell Biol. . 147 . 5 . 1073–84 . 1999 . 10579726 . 10.1083/jcb.147.5.1073 . 2169340 .
• Cirulli V, Beattie GM, Klier G, etal . Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells. . J. Cell Biol. . 150 . 6 . 1445–60 . 2000 . 10995448 . 10.1083/jcb.150.6.1445 . 2150716 .
• Albert ML, Kim JI, Birge RB . alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells. . Nat. Cell Biol. . 2 . 12 . 899–905 . 2001 . 11146654 . 10.1038/35046549 . 7535200 .
• Zhou M, Graham R, Russell G, Croucher PI . MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin. . Biochem. Biophys. Res. Commun. . 280 . 2 . 574–80 . 2001 . 11162558 . 10.1006/bbrc.2000.4155 .
• Niu JK, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN . The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion. . Eur J Cancer Prev . 16 . 6 . 517–27 . 2007 . 18090124 . 10.1097/CEJ.0b013e3280145c00 . 1825380 .

External links

• ITGB5 Info with links in the Cell Migration Gateway

Notes and References

1. McLean JW, Vestal DJ, Cheresh DA, Bodary SC . cDNA sequence of the human integrin beta 5 subunit . J Biol Chem . 265 . 28 . 17126–31 . Nov 1990 . 10.1016/S0021-9258(17)44878-2 . 2211615 . free .
2. Web site: Entrez Gene: ITGB5 integrin, beta 5.
3. Eliceiri . Brian P . Puente Xose S . Hood John D . Stupack Dwayne G . Schlaepfer David D . Huang Xiaozhu Z . Sheppard Dean . Cheresh David A . Apr 2002 . Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling . J. Cell Biol. . 157 . 1 . 149–60 . 0021-9525. 11927607 . 10.1083/jcb.200109079 . 2173263 .
4. Cardó-Vila . Marina . Arap Wadih . Pasqualini Renata . May 2003 . Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V . Mol. Cell . 11 . 5 . 1151–62 . 1097-2765. 12769841 . 10.1016/S1097-2765(03)00138-2 . free .
5. Zhang . Hongquan . Li Zhilun . Viklund Eva-Karin . Strömblad Staffan . Sep 2002 . P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration . J. Cell Biol. . 158 . 7 . 1287–97 . 0021-9525. 12356872 . 10.1083/jcb.200207008 . 2173231 .
6. Zhang . Lu-yang . Guo . Qing . Guan . Ge-fei . Cheng . Wen . Cheng . Peng . Wu . An-hua . 2019 . Integrin Beta 5 Is a Prognostic Biomarker and Potential Therapeutic Target in Glioblastoma . Frontiers in Oncology . 9 . 904 . 10.3389/fonc.2019.00904 . 31616629 . 6764112 . 2234-943X. free .
7. Coudert, AE . Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology. . Lab. Invest. . 94 . 3 . Mar 2014 . 24336069 . 275–285 . 10.1038/labinvest.2013.140. 5097233 . free .