Integrin beta 3 explained

Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene.^[1] CD61 is a cluster of differentiation found on thrombocytes.^[2]

Structure and function

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.^[3]

Role in endometriosis

Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition.^[4]

Interactions

CD61 has been shown to interact with PTK2,^{[5] [6]} ITGB3BP,^{[7] [8]} TLN1^{[9] [10]} and CIB1.^[11]

See also

• Glycoprotein IIb/IIIa

Further reading

• Bray PF . Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization. . Thromb. Haemost. . 72 . 4 . 492–502 . 1995 . 7878622 .
• Bennett JS . Platelet-fibrinogen interactions. . Ann. N. Y. Acad. Sci. . 936 . 1. 340–54 . 2001 . 11460491 . 10.1111/j.1749-6632.2001.tb03521.x . 2001NYASA.936..340B . 25431334 .
• Sajid M, Stouffer GA . The role of alpha(v)beta3 integrins in vascular healing. . Thromb. Haemost. . 87 . 2 . 187–93 . 2002 . 11858476 . 10.1055/s-0037-1612971.
• Quinn MJ, Byzova TV, Qin J . Integrin alphaIIbbeta3 and its antagonism. . Arterioscler. Thromb. Vasc. Biol. . 23 . 6 . 945–52 . 2004 . 12637342 . 10.1161/01.ATV.0000066686.46338.F1 . etal. free .
• Charakida M, Tousoulis D, Stefanadis C, Toutouzas P . The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease. . Italian Heart Journal . 4 . 1 . 17–22 . 2003 . 12690916 .
• Smith FB, Connor JM, Lee AJ . Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease. . Thromb. Res. . 112 . 4 . 209–16 . 2004 . 14987913 . 10.1016/j.thromres.2003.11.010 . etal.
• Fullard JF . The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis. . Curr. Pharm. Des. . 10 . 14 . 1567–76 . 2004 . 15134555 . 10.2174/1381612043384682 .
• Cacciari B, Spalluto G . Non peptidic alphavbeta3 antagonists: recent developments. . Curr. Med. Chem. . 12 . 1 . 51–70 . 2005 . 15638730 . 10.2174/0929867053363522.
• Watson SP, Auger JM, McCarty OJ, Pearce AC . GPVI and integrin alphaIIb beta3 signaling in platelets. . J. Thromb. Haemost. . 3 . 8 . 1752–62 . 2005 . 16102042 . 10.1111/j.1538-7836.2005.01429.x . 42666713 .
• Bennett JS . Structure and function of the platelet integrin alphaIIbbeta3. . J. Clin. Invest. . 115 . 12 . 3363–9 . 2006 . 16322781 . 10.1172/JCI26989 . 1297263 .

External links

• • ITGB3 Info with links in the Cell Migration Gateway

Notes and References

1. Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS . Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa . J Clin Invest . 81 . 6 . 1993–8 . August 1988 . 2454952 . 442653 . 10.1172/JCI113548 . etal.
2. Heemskerk. J. W. M.. Mattheij. N. J. A.. Cosemans. J. M. E. M.. Platelet-based coagulation: different populations, different functions. Journal of Thrombosis and Haemostasis. 11. 1. 2013. 2–16. 1538-7933. 10.1111/jth.12045. 23106920. 206157070. free.
3. Web site: Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61).
4. May . K. E. . Villar . J. . Kirtley . S. . Kennedy . S. H. . Becker . C. M. . Endometrial alterations in endometriosis: A systematic review of putative biomarkers . 10.1093/humupd/dmr013 . Human Reproduction Update . 17 . 5 . 637–653 . 2011 . 21672902. free .
5. Eliceiri . Brian P . Puente Xose S . Hood John D . Stupack Dwayne G . Schlaepfer David D . Huang Xiaozhu Z . Sheppard Dean . Cheresh David A . April 2002 . Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling . J. Cell Biol. . 157 . 1 . 149–60 . 0021-9525. 11927607 . 10.1083/jcb.200109079 . 2173263 .
6. Chung . J . Gao A G. Frazier W A . June 1997 . Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3 . J. Biol. Chem. . 272 . 23 . 14740–6 . 0021-9258. 9169439 . 10.1074/jbc.272.23.14740 . free .
7. Fujimoto . Tetsuro-Takahiro . Katsutani Shinya . Shimomura Takeshi . Fujimura Kingo . January 2002 . Novel alternatively spliced form of beta(3)-endonexin . Thromb. Res. . 105 . 1 . 63–70 . 0049-3848. 11864709 . 10.1016/S0049-3848(01)00405-4 .
8. Shattil . S J . O'Toole T. Eigenthaler M. Thon V. Williams M. Babior B M. Ginsberg M H . November 1995 . Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit . J. Cell Biol. . 131 . 3 . 807–16 . 0021-9525. 7593198 . 10.1083/jcb.131.3.807 . 2120613 .
9. Patil . S . Jedsadayanmata A. Wencel-Drake J D. Wang W. Knezevic I. Lam S C . October 1999 . Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail . J. Biol. Chem. . 274 . 40 . 28575–83 . 0021-9258. 10497223 . 10.1074/jbc.274.40.28575 . free .
10. Calderwood . David A . Yan Boxu . de Pereda Jose M . Alvarez Begoña García . Fujioka Yosuke . Liddington Robert C . Ginsberg Mark H . June 2002 . The phosphotyrosine binding-like domain of talin activates integrins . J. Biol. Chem. . 277 . 24 . 21749–58 . 0021-9258. 11932255 . 10.1074/jbc.M111996200 . free .
11. Naik . U P . Patel P M. Parise L V . February 1997 . Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain . J. Biol. Chem. . 272 . 8 . 4651–4 . 0021-9258. 9030514 . 10.1074/jbc.272.8.4651 . free .