Integrin alpha 8 explained

Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene.^{[1] [2]}

Further reading

• Schnapp LM, Hatch N, Ramos DM, etal . The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. . J. Biol. Chem. . 270 . 39 . 23196–202 . 1995 . 7559467 . 10.1074/jbc.270.39.23196 . free.
• Denda S, Müller U, Crossin KL, etal . Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C. . Biochemistry . 37 . 16 . 5464–74 . 1998 . 9548928 . 10.1021/bi9727489 . 2710129 .
• Hartner A, Schöcklmann H, Pröls F, etal . Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis. . Kidney Int. . 56 . 4 . 1468–80 . 1999 . 10504498 . 10.1046/j.1523-1755.1999.00662.x . free .
• Littlewood Evans A, Müller U . Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1. . Nat. Genet. . 24 . 4 . 424–8 . 2000 . 10742111 . 10.1038/74286 . 2316181 .
• Brandenberger R, Schmidt A, Linton J, etal . Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney. . J. Cell Biol. . 154 . 2 . 447–58 . 2001 . 11470831 . 10.1083/jcb.200103069 . 2150762 .
• Ljubimov AV, Saghizadeh M, Pytela R, etal . Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. . J. Histochem. Cytochem. . 49 . 11 . 1341–50 . 2001 . 11668187 . 10.1177/002215540104901102. free .
• Valerius MT, Patterson LT, Feng Y, Potter SS . Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 12 . 8090–5 . 2002 . 12060755 . 10.1073/pnas.122229199 . 123025 . 2002PNAS...99.8090V . free .
• Lu M, Munger JS, Steadele M, etal . Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1. . J. Cell Sci. . 115 . Pt 23 . 4641–8 . 2003 . 12415008 . 10.1242/jcs.00145 . free .
• Bieritz B, Spessotto P, Colombatti A, etal . Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation. . Kidney Int. . 64 . 1 . 119–27 . 2004 . 12787402 . 10.1046/j.1523-1755.2003.00057.x . free .
• Deloukas P, Earthrowl ME, Grafham DV, etal . The DNA sequence and comparative analysis of human chromosome 10. . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . free .
• Ekwa-Ekoka C, Diaz GA, Carlson C, etal . Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8). . Matrix Biol. . 23 . 7 . 487–96 . 2005 . 15579315 . 10.1016/j.matbio.2004.08.005 .
• Scherberich A, Tucker RP, Degen M, etal . Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro. . Oncogene . 24 . 9 . 1525–32 . 2005 . 15592496 . 10.1038/sj.onc.1208342 . free .

External links

• ITGA8 Info with links in the Cell Migration Gateway

Notes and References

1. Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R . Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells . J Cell Sci . 108 . 2. 537–44 . Jul 1995 . 10.1242/jcs.108.2.537 . 7768999 .
2. Web site: Entrez Gene: ITGA8 integrin, alpha 8.