Integrin alpha 5 explained

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.^[1]

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.^[2]

Interactions

ITGA5 has been shown to interact with GIPC1.^[3]

See also

• Cluster of differentiation
• Integrin

Further reading

• Ruoslahti E . Integrin signaling and matrix assembly. . Tumour Biol. . 17 . 2 . 117–24 . 1996 . 8658014 . 10.1159/000217975 .
• Coulombel L, Auffray I, Gaugler MH, Rosemblatt M . Expression and function of integrins on hematopoietic progenitor cells. . Acta Haematol. . 97 . 1–2 . 13–21 . 1997 . 8980606 . 10.1159/000203655 .
• Porter JC, Hogg N . Integrins take partners: cross-talk between integrins and other membrane receptors . Trends Cell Biol. . 8 . 10 . 390–6 . 1999 . 9789327 . 10.1016/S0962-8924(98)01344-0 .
• Evans JP . Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization . BioEssays . 23 . 7 . 628–39 . 2001 . 11462216 . 10.1002/bies.1088 . 23712246 .

External links

• • ITGA5 Info with links in the Cell Migration Gateway

Notes and References

1. Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS . Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa . J Clin Invest . 81 . 6 . 1993–8 . Aug 1988 . 2454952 . 442653 . 10.1172/JCI113548 . etal.
2. Web site: Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide).
3. Tani . T T . Mercurio A M . Sep 2001 . PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B . J. Biol. Chem. . 276 . 39 . 36535–42 . United States. 0021-9258. 11479315 . 10.1074/jbc.M105785200 . free.