Integrin alpha 2b explained

Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered.^[1] In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.^[2]

Interactions

ITGA2B has been shown to interact with AUP1^[3] and CLNS1A.^[4]

See also

• Cluster of differentiation
• Glycoprotein IIb/IIIa

Further reading

• Bray PF . Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization. . Thromb. Haemost. . 72 . 4 . 492–502 . 1995 . 7878622 .
• Naik UP, Parise LV . Structure and function of platelet alpha IIb beta 3. . Curr. Opin. Hematol. . 4 . 5 . 317–22 . 1997 . 9288464 . 10.1097/00062752-199704050-00004.
• Porter JC, Hogg N . Integrins take partners: cross-talk between integrins and other membrane receptors. . Trends Cell Biol. . 8 . 10 . 390–6 . 1999 . 9789327 . 10.1016/S0962-8924(98)01344-0 .
• Lincoff AM . Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary revascularization. . Am. J. Cardiol. . 82 . 8B . 36P–42P . 1998 . 9809890 . 10.1016/S0002-9149(98)00662-6 .
• Bennett JS . Platelet-fibrinogen interactions. . Ann. N. Y. Acad. Sci. . 936 . 340–54 . 2001 . 1 . 11460491 . 10.1111/j.1749-6632.2001.tb03521.x . 2001NYASA.936..340B . 25431334 .
• Plow EF, Cierniewski CS, Xiao Z, etal . AlphaIIbbeta3 and its antagonism at the new millennium. . Thromb. Haemost. . 86 . 1 . 34–40 . 2002 . 11487023 . 10.1055/s-0037-1616198. 74389210 .
• Quinn MJ, Byzova TV, Qin J, etal . Integrin alphaIIbbeta3 and its antagonism. . Arterioscler. Thromb. Vasc. Biol. . 23 . 6 . 945–52 . 2004 . 12637342 . 10.1161/01.ATV.0000066686.46338.F1 . free .
• Fullard JF . The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis. . Curr. Pharm. Des. . 10 . 14 . 1567–76 . 2004 . 15134555 . 10.2174/1381612043384682 .
• Watson SP, Auger JM, McCarty OJ, Pearce AC . GPVI and integrin alphaIIb beta3 signaling in platelets. . J. Thromb. Haemost. . 3 . 8 . 1752–62 . 2005 . 16102042 . 10.1111/j.1538-7836.2005.01429.x . 42666713 . free .
• Bennett JS . Structure and function of the platelet integrin alphaIIbbeta3. . J. Clin. Invest. . 115 . 12 . 3363–9 . 2006 . 16322781 . 10.1172/JCI26989 . 1297263 .
• Ma YQ, Qin J, Plow EF . Platelet integrin alpha(IIb)beta(3): activation mechanisms. . J. Thromb. Haemost. . 5 . 7 . 1345–52 . 2007 . 17635696 . 10.1111/j.1538-7836.2007.02537.x . 12983526 .

Notes and References

1. Šimčíková D, Heneberg P . Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases . Scientific Reports . 9 . 1 . 18577 . December 2019 . 31819097 . 6901466 . 10.1038/s41598-019-54976-4. 2019NatSR...918577S .
2. Web site: Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41).
3. Kato . Atsushi . Kawamata Norihiko . Tamayose Kenji . Egashira Motoki . Miura Rika . Fujimura Tsutomu . Murayama Kimie . Oshimi Kazuo . Aug 2002 . Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3 . J. Biol. Chem. . 277 . 32 . 28934–41 . United States. 0021-9258. 12042322 . 10.1074/jbc.M204340200 . free .
4. Larkin . Deirdre . Murphy Derek . Reilly Dermot F . Cahill Martha . Sattler Ellen . Harriott Pat . Cahill Dolores J . Moran Niamh . Jun 2004 . ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation . J. Biol. Chem. . 279 . 26 . 27286–93 . United States. 0021-9258. 15075326 . 10.1074/jbc.M402159200 . free .