IRF9 explained

Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G.^{[1] [2] [3]}

Interactions

IRF9 has been shown to interact with STAT2^{[4] [5]} and STAT1.^[4]

Further reading

• Cebulla CM, Miller DM, Sedmak DD . Viral inhibition of interferon signal transduction . Intervirology . 42 . 5–6 . 325–30 . 2000 . 10702714 . 10.1159/000053968 . 22135982 .
• Reich NC . Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation . J. Interferon Cytokine Res. . 22 . 1 . 103–9 . 2002 . 11846981 . 10.1089/107999002753452719 .
• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, etal . Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening . Genomics . 23 . 1 . 42–50 . 1995 . 7829101 . 10.1006/geno.1994.1457 .
• David M, Romero G, Zhang ZY, etal . In vitro activation of the transcription factor ISGF3 by interferon alpha involves a membrane-associated tyrosine phosphatase and tyrosine kinase . J. Biol. Chem. . 268 . 9 . 6593–9 . 1993 . 10.1016/S0021-9258(18)53292-0 . 8454630 . free .
• Horvath CM, Stark GR, Kerr IM, Darnell JE . Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex . Mol. Cell. Biol. . 16 . 12 . 6957–64 . 1997 . 8943351 . 10.1128/mcb.16.12.6957. 231699 .
• Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC . Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3 . J. Biol. Chem. . 272 . 32 . 20070–6 . 1997 . 9242679 . 10.1074/jbc.272.32.20070 . free .
• Reddy PH, Stockburger E, Gillevet P, Tagle DA . Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method . Genomics . 46 . 2 . 174–82 . 1998 . 9417904 . 10.1006/geno.1997.5044 .
• Lau JF, Parisien JP, Horvath CM . Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors . Proc. Natl. Acad. Sci. U.S.A. . 97 . 13 . 7278–83 . 2000 . 10860992 . 10.1073/pnas.97.13.7278 . 16536 . 2000PNAS...97.7278L . free .
• Nehyba J, Hrdlicková R, Burnside J, Bose HR . A Novel Interferon Regulatory Factor (IRF), IRF-10, Has a Unique Role in Immune Defense and Is Induced by the v-Rel Oncoprotein . Mol. Cell. Biol. . 22 . 11 . 3942–57 . 2002 . 11997525 . 10.1128/MCB.22.11.3942-3957.2002 . 133824 .
• Chawla-Sarkar M, Leaman DW, Jacobs BS, etal . Resistance to interferons in melanoma cells does not correlate with the expression or activation of signal transducer and activator of transcription 1 (Stat1) . J. Interferon Cytokine Res. . 22 . 5 . 603–13 . 2002 . 12060499 . 10.1089/10799900252982089 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Lau JF, Nusinzon I, Burakov D, etal . Role of Metazoan Mediator Proteins in Interferon-Responsive Transcription . Mol. Cell. Biol. . 23 . 2 . 620–8 . 2003 . 12509459 . 10.1128/MCB.23.2.620-628.2003 . 151539 .
• Jikuya H, Takano J, Kikuno R, etal . Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones . DNA Res. . 10 . 1 . 49–57 . 2003 . 12693554 . 10.1093/dnares/10.1.49 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Thompson HG, Harris JW, Lin L, Brody JP . Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells . Exp. Cell Res. . 295 . 2 . 448–59 . 2004 . 15093743 . 10.1016/j.yexcr.2004.01.019 .
• Sakamoto S, Potla R, Larner AC . Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes . J. Biol. Chem. . 279 . 39 . 40362–7 . 2004 . 15194680 . 10.1074/jbc.M406400200 . free .

Notes and References

1. Veals SA, Schindler C, Leonard D, Fu XY, Aebersold R, ((Darnell JE Jr)), Levy DE . Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins . Mol Cell Biol . 12 . 8 . 3315–24 . Aug 1992 . 1630447 . 364572 . 10.1128/MCB.12.8.3315.
2. McCusker D, Wilson M, Trowsdale J . Organization of the genes encoding the human proteasome activators PA28alpha and beta . Immunogenetics . 49 . 5 . 438–45 . Jun 1999 . 10199920 . 10.1007/s002510050517 . 40575791 .
3. Web site: Entrez Gene: ISGF3G interferon-stimulated transcription factor 3, gamma 48kDa.
4. Horvath . C M . Stark G R . Kerr I M . Darnell J E . Dec 1996 . Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex . Mol. Cell. Biol. . 16 . 12 . 6957–64 . UNITED STATES. 0270-7306. 8943351 . 231699 . 10.1128/mcb.16.12.6957.
5. Martinez-Moczygemba . M . Gutch M J . French D L . Reich N C . Aug 1997 . Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3 . J. Biol. Chem. . 272 . 32 . 20070–6 . UNITED STATES. 0021-9258. 9242679 . 10.1074/jbc.272.32.20070 . free .