IRX4 explained

Iroquois-class homeodomain protein IRX-4, also known as Iroquois homeobox protein 4, is a protein that in humans is encoded by the IRX4 gene.^{[1] [2]}

Function

IRX4 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.^[1]

Further reading

• Lewis MT, Ross S, Strickland PA, etal . Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. . Cell Tissue Res. . 296 . 3 . 549–54 . 1999 . 10370142 . 10.1007/s004410051316. 37046813 .
• Wang GF, Nikovits W, Bao ZZ, Stockdale FE . Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression. . J. Biol. Chem. . 276 . 31 . 28835–41 . 2001 . 11382777 . 10.1074/jbc.M103716200 . free .
• Bayrak F, Kömürcü-Bayrak E, Mutlu B, etal . Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy. . Turk Kardiyol Dern Ars . 36 . 2 . 90–5 . 2008 . 18497553 .
• Cirulli ET, Kasperavičiūtė D, Attix DK, etal . Common genetic variation and performance on standardized cognitive tests. . European Journal of Human Genetics . 18. 7. 815–820 . 2010 . 20125193 . 10.1038/ejhg.2010.2 . 2987367.
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .

Notes and References

1. Web site: Entrez Gene: iroquois homeobox 4.
2. Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE . Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand . Dev. Biol. . 217 . 2 . 266–77 . January 2000 . 10625552 . 10.1006/dbio.1999.9548 . free .