IRF2BP2 explained
Interferon regulatory factor 2 binding protein 2 is a protein that in humans is encoded by the IRF2BP2 gene.[1]
Function
This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Further reading
- Childs KS, Goodbourn S . Identification of novel co-repressor molecules for Interferon Regulatory Factor-2 . Nucleic Acids Res. . 31 . 12 . 3016–26 . 2003 . 12799427 . 162335 . 10.1093/nar/gkg431.
- Tinnikov AA, Yeung KT, Das S, Samuels HH . Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells . Cancer Res. . 69 . 4 . 1375–82 . 2009 . 19190336 . 4264605 . 10.1158/0008-5472.CAN-08-2896 .
- Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF . IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression . FASEB J. . 24 . 12 . 4825–34 . 2010 . 20702774 . 10.1096/fj.10-167049 . free . 35708173 .
- Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF . IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression . FASEB J. . 24 . 12 . 4825–34 . 2010 . 20702774 . 10.1096/fj.10-167049 . free . 35708173 .
- Carneiro FR, Ramalho-Oliveira R, Mognol GP, Viola JP . Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity . Mol. Cell. Biol. . 31 . 14 . 2889–901 . 2011 . 21576369 . 3133407 . 10.1128/MCB.00974-10 .
- Teng AC, Al-Montashiri NA, Cheng BL, Lou P, Ozmizrak P, Chen HH, Stewart AF . Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2 . PLOS ONE . 6 . 8 . e24100 . 2011 . 21887377 . 3162591 . 10.1371/journal.pone.0024100 . 2011PLoSO...624100T . free .
- Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F . Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma . PLOS ONE . 7 . 11 . e49705 . 2012 . 23185413 . 3504151 . 10.1371/journal.pone.0049705 . 2012PLoSO...749705N . free .
Notes and References
- Web site: Entrez Gene: Interferon regulatory factor 2 binding protein 2. 2017-01-06.
