IRAK3 explained

Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene.^{[1] [2]} Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced expression of A20 and VE-cadherin in endothelial cells. Thus, IRAK3 is crucial for maintenance and repair of endothelial barrier after endotoxin-induced lung injury.^[3]

Further reading

• Rosati O, Martin MU . Identification and characterization of murine IRAK-M . Biochemical and Biophysical Research Communications . 293 . 5 . 1472–7 . May 2002 . 12054681 . 10.1016/S0006-291X(02)00411-4 .
• Bin LH, Xu LG, Shu HB . TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling . The Journal of Biological Chemistry . 278 . 27 . 24526–32 . July 2003 . 12721283 . 10.1074/jbc.M303451200 . free .
• Escoll P, del Fresno C, García L, Vallés G, Lendínez MJ, Arnalich F, López-Collazo E . Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients . Biochemical and Biophysical Research Communications . 311 . 2 . 465–72 . November 2003 . 14592437 . 10.1016/j.bbrc.2003.10.019 .
• del Fresno C, Otero K, Gómez-García L, González-León MC, Soler-Ranger L, Fuentes-Prior P, Escoll P, Baos R, Caveda L, García F, Arnalich F, López-Collazo E . Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4 . Journal of Immunology . 174 . 5 . 3032–40 . March 2005 . 15728517 . 10.4049/jimmunol.174.5.3032 . free .
• Su J, Xie Q, Wilson I, Li L . Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling . Cellular Signalling . 19 . 7 . 1596–601 . July 2007 . 17379480 . 1978187 . 10.1016/j.cellsig.2007.02.009 .
• Balaci L, Spada MC, Olla N, Sole G, Loddo L, Anedda F, Naitza S, Zuncheddu MA, Maschio A, Altea D, Uda M, Pilia S, Sanna S, Masala M, Crisponi L, Fattori M, Devoto M, Doratiotto S, Rassu S, Mereu S, Giua E, Cadeddu NG, Atzeni R, Pelosi U, Corrias A, Perra R, Torrazza PL, Pirina P, Ginesu F, Marcias S, Schintu MG, Del Giacco GS, Manconi PE, Malerba G, Bisognin A, Trabetti E, Boner A, Pescollderungg L, Pignatti PF, Schlessinger D, Cao A, Pilia G . IRAK-M is involved in the pathogenesis of early-onset persistent asthma . American Journal of Human Genetics . 80 . 6 . 1103–14 . June 2007 . 17503328 . 1867098 . 10.1086/518259 .
• Weersma RK, Oostenbrug LE, Nolte IM, Van Der Steege G, Oosterom E, Van Dullemen HM, Kleibeuker JH, Dijkstra G . Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases . Scandinavian Journal of Gastroenterology . 42 . 7 . 827–33 . July 2007 . 17558906 . 10.1080/00365520601114024 . 22703718 .
• van 't Veer C, van den Pangaart PS, van Zoelen MA, de Kruif M, Birjmohun RS, Stroes ES, de Vos AF, van der Poll T . Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model . Journal of Immunology . 179 . 10 . 7110–20 . November 2007 . 17982103 . 10.4049/jimmunol.179.10.7110 . free .

Notes and References

1. Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z . IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family . The Journal of Biological Chemistry . 274 . 27 . 19403–10 . July 1999 . 10383454 . 10.1074/jbc.274.27.19403 . free .
2. Web site: Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3.
3. Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schlüter D, Tiruppathi C . Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury . Cell Death Discovery . 4 . 60 . May 2018 . 60 . 29796309. 5955943 . 10.1038/s41420-018-0056-3.