IQGAP2 explained

Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene.^{[1] [2]}

Function

This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.

Interactions

IQGAP2 has been shown to interact with CDC42 and RAC1.^[1]

Further reading

• McCallum SJ, Wu WJ, Cerione RA . Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2 . J. Biol. Chem. . 271 . 36 . 21732–7 . 1996 . 8702968 . 10.1074/jbc.271.36.21732 . free .
• Yin H, Morioka H, Towle CA, Vidal M, Watanabe T, Weissbach L . Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein . Cytokine . 15 . 3 . 122–37 . 2001 . 11554782 . 10.1006/cyto.2001.0891 .
• Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ . RhoG signals in parallel with Rac1 and Cdc42 . J. Biol. Chem. . 277 . 49 . 47810–7 . 2002 . 12376551 . 10.1074/jbc.M203816200 . free .
• Schmidt VA, Scudder L, Devoe CE, Bernards A, Cupit LD, Bahou WF . IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization . Blood . 101 . 8 . 3021–8 . 2003 . 12515716 . 10.1182/blood-2002-09-2807 . free .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2003 . 12665801 . 10.1038/nbt810 . 23783563 .
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Chew CS, Okamoto CT, Chen X, Qin HY . IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells . Am. J. Physiol. Gastrointest. Liver Physiol. . 288 . 2 . G376-87 . 2005 . 15458922 . 10.1152/ajpgi.00290.2004 .
• Wang H, Huo R, Xu M, Lu L, Xu Z, Li J, Zhou Z, Sha J . Cloning and characterization of a novel transcript variant of IQGAP2 in human testis . DNA Seq. . 15 . 5–6 . 319–25 . 2005 . 15621655 . 10.1080/10425170400009012 . 22014226 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Brill S, Li S, Lyman CW, Church DM, Wasmuth JJ, Weissbach L, Bernards A, Snijders AJ . The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases . Mol. Cell. Biol. . 16 . 9 . 4869–78 . Sep 1996 . 8756646 . 231489 . 10.1128/mcb.16.9.4869.
2. Web site: Entrez Gene: IQGAP2 IQ motif containing GTPase activating protein 2.