IQCB1 explained

IQ calmodulin-binding motif-containing protein 1 is a protein that in humans is encoded by the IQCB1 gene.^{[1] [2]}

Further reading

• Nomura N, Miyajima N, Sazuka T, etal . Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. . DNA Res. . 1 . 1 . 27–35 . 1995 . 7584026 . 10.1093/dnares/1.1.27 . free .
• Nomura N, Miyajima N, Sazuka T, etal . Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). . DNA Res. . 1 . 1 . 47–56 . 1995 . 7584028 . 10.1093/dnares/1.1.47 . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Mollet G, Salomon R, Gribouval O, etal . The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin. . Nat. Genet. . 32 . 2 . 300–5 . 2002 . 12244321 . 10.1038/ng996 . 24216974 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Mollet G, Silbermann F, Delous M, etal . Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes. . Hum. Mol. Genet. . 14 . 5 . 645–56 . 2005 . 15661758 . 10.1093/hmg/ddi061 . free .
• le Maire A, Weber T, Saunier S, etal . Solution NMR structure of the SH3 domain of human nephrocystin and analysis of a mutation-causing juvenile nephronophthisis. . Proteins . 59 . 2 . 347–55 . 2006 . 15723349 . 10.1002/prot.20344 . 37333782 .
• Luo X, He Q, Huang Y, Sheikh MS . Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers. . Cancer Res. . 65 . 23 . 10725–33 . 2006 . 16322217 . 10.1158/0008-5472.CAN-05-1132 . free .

Notes and References

1. Otto EA, Loeys B, Khanna H, Hellemans J, Sudbrak R, Fan S, Muerb U, O'Toole JF, Helou J, Attanasio M, Utsch B, Sayer JA, Lillo C, Jimeno D, Coucke P, De Paepe A, Reinhardt R, Klages S, Tsuda M, Kawakami I, Kusakabe T, Omran H, Imm A, Tippens M, Raymond PA, Hill J, Beales P, He S, Kispert A, Margolis B, Williams DS, Swaroop A, Hildebrandt F . Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin . Nat Genet . 37 . 3 . 282–8 . Feb 2005 . 15723066 . 10.1038/ng1520 . 4972004 .
2. Web site: Entrez Gene: IQCB1 IQ motif containing B1.