IPO8 explained
Importin 8 is a protein that in humans is encoded by the IPO8 gene.[1]
Function
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
Further reading
- Görlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E . A novel class of RanGTP binding proteins . The Journal of Cell Biology . 138 . 1 . 65–80 . July 1997 . 9214382 . 2139951 . 10.1083/jcb.138.1.65 .
- Nozawa RS, Nagao K, Masuda HT, Iwasaki O, Hirota T, Nozaki N, Kimura H, Obuse C . Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation . Nature Cell Biology . 12 . 7 . 719–27 . July 2010 . 20562864 . 10.1038/ncb2075 . 7389788 .
- Lunetta KL, D'Agostino RB, Karasik D, Benjamin EJ, Guo CY, Govindaraju R, Kiel DP, Kelly-Hayes M, Massaro JM, Pencina MJ, Seshadri S, Murabito JM . Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study . BMC Medical Genetics . 8 . S13 . September 2007 . Suppl 1 . 17903295 . 1995604 . 10.1186/1471-2350-8-S1-S13 . free .
- Nguewa PA, Agorreta J, Blanco D, Lozano MD, Gomez-Roman J, Sanchez BA, Valles I, Pajares MJ, Pio R, Rodriguez MJ, Montuenga LM, Calvo A . Identification of importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens . BMC Molecular Biology . 9 . 103 . November 2008 . 19014639 . 2612021 . 10.1186/1471-2199-9-103 . free .
- Dean KA, von Ahsen O, Görlich D, Fried HM . Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin . Journal of Cell Science . 114 . Pt 19 . 3479–85 . October 2001 . 10.1242/jcs.114.19.3479 . 11682607 . 11858/00-001M-0000-0015-3D81-6 . free .
- Weinmann L, Höck J, Ivacevic T, Ohrt T, Mütze J, Schwille P, Kremmer E, Benes V, Urlaub H, Meister G . Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs . Cell . 136 . 3 . 496–507 . February 2009 . 19167051 . 10.1016/j.cell.2008.12.023 . 11858/00-001M-0000-0012-D8E1-E . 15876600 . free .
- Yao X, Chen X, Cottonham C, Xu L . Preferential utilization of Imp7/8 in nuclear import of Smads . The Journal of Biological Chemistry . 283 . 33 . 22867–74 . August 2008 . 18519565 . 2504884 . 10.1074/jbc.M801320200 . free .
- Zuo S, Xue Y, Tang S, Yao J, Du R, Yang P, Chen X . 14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity . Journal of Proteome Research . 9 . 7 . 3465–78 . July 2010 . 20462248 . 10.1021/pr9011377 .
Notes and References
- Web site: Entrez Gene: Importin 8 .