INTS6 explained

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.^{[1] [2] [3]}

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.^[3]

Further reading

• Buchsbaum S, Morris C, Bochard V, Jalinot P . Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle. . Oncogene . 26 . 35 . 5132–44 . 2007 . 17310990 . 10.1038/sj.onc.1210314 . 2886919 .
• Hernández M, Papadopoulos N, Almeida TA . Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions. . Cancer Genet. Cytogenet. . 163 . 1 . 91–2 . 2006 . 16271964 . 10.1016/j.cancergencyto.2005.04.014 .
• Röpke A, Buhtz P, Böhm M, etal . Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer. . Oncogene . 24 . 44 . 6667–75 . 2005 . 16007164 . 10.1038/sj.onc.1208824 . 12129480 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wieland I, Sell C, Weidle UH, Wieacker P . Ectopic expression of DICE1 suppresses tumor cell growth. . Oncol. Rep. . 12 . 2 . 207–11 . 2005 . 15254679 . 10.3892/or.12.2.207.
• Dunham A, Matthews LH, Burton J, etal . The DNA sequence and analysis of human chromosome 13. . Nature . 428 . 6982 . 522–8 . 2004 . 15057823 . 10.1038/nature02379 . 2665288 . 2004Natur.428..522D .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Li WJ, Hu N, Su H, etal . Allelic loss on chromosome 13q14 and mutation in deleted in cancer 1 gene in esophageal squamous cell carcinoma. . Oncogene . 22 . 2 . 314–8 . 2003 . 12527901 . 10.1038/sj.onc.1206098 . 10839440 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Wieland I, Röpke A, Stumm M, etal . Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells. . Oncol. Res. . 12 . 11–12 . 491–500 . 2002 . 10.3727/096504001108747503 . 11939413 . free .
• Camargo AA, Nunes DN, Samaia HB, etal . Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12. . Braz. J. Med. Biol. Res. . 34 . 10 . 1237–45 . 2002 . 11593297 . 10.1590/s0100-879x2001001000002. free .

Notes and References

1. Wieland I, Arden KC, Michels D, Klein-Hitpass L, Bohm M, Viars CS, Weidle UH . Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas . Oncogene . 18 . 32 . 4530–7 . Oct 1999 . 10467397 . 10.1038/sj.onc.1202806 . free .
2. Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R . Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II . Cell . 123 . 2 . 265–76 . Oct 2005 . 16239144 . 10.1016/j.cell.2005.08.019 . free .
3. Web site: Entrez Gene: INTS6 integrator complex subunit 6.