INPP5F explained
Inositol polyphosphate-5-phosphatase F is a protein that in humans is encoded by the INPP5F gene.[1]
Function
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].
Further reading
- Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A . A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease . Am. J. Hum. Genet. . 78 . 1 . 78–88 . January 2006 . 16385451 . 1380225 . 10.1086/498851 .
- Zhu W, Trivedi CM, Zhou D, Yuan L, Lu MM, Epstein JA . Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness . Circ. Res. . 105 . 12 . 1240–7 . December 2009 . 19875726 . 2802340 . 10.1161/CIRCRESAHA.109.208785 .
- Kim HS, Li A, Ahn S, Song H, Zhang W . Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity . Sci Rep . 4 . 7330 . December 2014 . 25476455 . 4256660 . 10.1038/srep07330 . 2014NatSR...4E7330K .
- Hsu F, Hu F, Mao Y . Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling . J. Cell Biol. . 209 . 1 . 97–110 . April 2015 . 25869669 . 4395482 . 10.1083/jcb.201408027 .
Notes and References
- Web site: Entrez Gene: Inositol polyphosphate-5-phosphatase F. 2018-05-14.