INPP5B explained

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.^{[1] [2]}

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[3]

Further reading

• Mitchell CA, Connolly TM, Majerus PW . Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets. . J. Biol. Chem. . 264 . 15 . 8873–7 . 1989 . 10.1016/S0021-9258(18)81874-9 . 2542294 . free .
• Jefferson AB, Majerus PW . Properties of type II inositol polyphosphate 5-phosphatase. . J. Biol. Chem. . 270 . 16 . 9370–7 . 1995 . 7721860 . 10.1074/jbc.270.16.9370 . free .
• Jänne PA, Dutra AS, Dracopoli NC, etal . Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34. . Cytogenet. Cell Genet. . 66 . 3 . 164–6 . 1994 . 8125013 . 10.1159/000133691 .
• Speed CJ, Matzaris M, Bird PI, Mitchell CA . Tissue distribution and intracellular localisation of the 75-kDa inositol polyphosphate 5-phosphatase. . Eur. J. Biochem. . 234 . 1 . 216–24 . 1996 . 8529643 . 10.1111/j.1432-1033.1995.216_c.x . free .
• Jänne PA, Rochelle JM, Martin-DeLeon PA, etal . Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens. . Genomics . 28 . 2 . 280–5 . 1996 . 8530037 . 10.1006/geno.1995.1142 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Barrios-Rodiles M, Brown KR, Ozdamar B, etal . High-throughput mapping of a dynamic signaling network in mammalian cells. . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .

Notes and References

1. Ross TS, Jefferson AB, Mitchell CA, Majerus PW . Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase . J Biol Chem . 266 . 30 . 20283–9 . Dec 1991 . 10.1016/S0021-9258(18)54920-6 . 1718960 . free .
2. Web site: Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa.
3. Web site: Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa.