INPP4B explained

Inositol polyphosphate-4-phosphatase, type II, 105kDa is a protein that in humans is encoded by the INPP4B gene.^[1]

INPP4B encodes the inositol polyphosphate 4-phosphatase type II, a dual specificity phosphatase. INPP4B is involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate and phosphate groups from phosphotyrosines.^[2] There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme.^[1]

Further reading

• Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, Rosen BP, Agoulnik IU . Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities . Biochemical and Biophysical Research Communications . 440 . 2 . 277–82 . October 2013 . 24070612 . 4578723 . 10.1016/j.bbrc.2013.09.077 .
• Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC . Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling . Cancer Cell . 16 . 2 . 115–25 . August 2009 . 19647222 . 2957372 . 10.1016/j.ccr.2009.06.006 .
• Hodgson MC, Shao LJ, Frolov A, Li R, Peterson LE, Ayala G, Ittmann MM, Weigel NL, Agoulnik IU . Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer . Cancer Research . 71 . 2 . 572–82 . January 2011 . 21224358 . 3077543 . 10.1158/0008-5472.CAN-10-2314 .
• Norris FA, Atkins RC, Majerus PW . The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family . The Journal of Biological Chemistry . 272 . 38 . 23859–64 . September 1997 . 9295334 . 10.1074/jbc.272.38.23859 . free .
• Munday AD, Norris FA, Caldwell KK, Brown S, Majerus PW, Mitchell CA . The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol . Proceedings of the National Academy of Sciences of the United States of America . 96 . 7 . 3640–5 . March 1999 . 10097090 . 22347 . 10.1073/pnas.96.7.3640 . 1999PNAS...96.3640M . free .
• Amato R, Pinelli M, Monticelli A, Miele G, Cocozza S . Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation . BMC Evolutionary Biology . 10 . 351 . November 2010 . 1 . 21070662 . 2996405 . 10.1186/1471-2148-10-351 . 2010BMCEE..10..351A . free .
• Norris FA, Auethavekiat V, Majerus PW . The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase . The Journal of Biological Chemistry . 270 . 27 . 16128–33 . July 1995 . 7608176 . 10.1074/jbc.270.27.16128 . free .
• Rampersaud E, Damcott CM, Fu M, Shen H, McArdle P, Shi X, Shelton J, Yin J, Chang YP, Ott SH, Zhang L, Zhao Y, Mitchell BD, O'Connell J, Shuldiner AR . Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations . Diabetes . 56 . 12 . 3053–62 . December 2007 . 17846126 . 10.2337/db07-0457 . free .
• Fedele CG, Ooms LM, Ho M, Vieusseux J, O'Toole SA, Millar EK, Lopez-Knowles E, Sriratana A, Gurung R, Baglietto L, Giles GG, Bailey CG, Rasko JE, Shields BJ, Price JT, Majerus PW, Sutherland RL, Tiganis T, McLean CA, Mitchell CA . Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers . Proceedings of the National Academy of Sciences of the United States of America . 107 . 51 . 22231–6 . December 2010 . 21127264 . 3009830 . 10.1073/pnas.1015245107 . 2010PNAS..10722231F . free .
• Zhang X, Majerus PW . Phosphatidylinositol signalling reactions . Seminars in Cell & Developmental Biology . 9 . 2 . 153–60 . April 1998 . 9599410 . 10.1006/scdb.1997.0220 .
• Agoulnik IU, Hodgson MC, Bowden WA, Ittmann MM . INPP4B: the new kid on the PI3K block . Oncotarget . 2 . 4 . 321–8 . April 2011 . 21487159 . 3248162 . 10.18632/oncotarget.260 .

Notes and References

1. Web site: Entrez Gene: Inositol polyphosphate-4-phosphatase, type II, 105kDa . 2012-07-24 .
2. Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, Rosen BP, Agoulnik IU . Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities . Biochemical and Biophysical Research Communications . 440 . 2 . 277–82 . October 2013 . 24070612 . 4578723 . 10.1016/j.bbrc.2013.09.077 .