INPP1 explained

Inositol polyphosphate 1-phosphatase is an enzyme that, in humans, is encoded by the INPP1 gene.^{[1] [2]} INPP1 encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate.^[2]

Further reading

• Majerus PW, Ross TS, Cunningham TW, etal . Recent insights in phosphatidylinositol signaling. . Cell . 63 . 3 . 459–65 . 1990 . 2225061 . 10.1016/0092-8674(90)90442-H . 29563486 .
• Zhang X, Majerus PW . Phosphatidylinositol signalling reactions. . Semin. Cell Dev. Biol. . 9 . 2 . 153–60 . 1998 . 9599410 . 10.1006/scdb.1997.0220 .
• Steen VM, Løvlie R, Osher Y, etal . The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness. . Pharmacogenetics . 8 . 3 . 259–68 . 1998 . 9682271 . 10.1097/00008571-199806000-00008.
• Løvlie R, Gulbrandsen AK, Molven A, Steen VM . Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1). . Pharmacogenetics . 9 . 4 . 517–28 . 2000 . 10780272 .
• Patel S, Yenush L, Rodríguez PL, etal . Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy. . J. Mol. Biol. . 315 . 4 . 677–85 . 2002 . 11812139 . 10.1006/jmbi.2001.5271 .
• Piccardi MP, Ardau R, Chillotti C, etal . Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes. . Psychiatr. Genet. . 12 . 1 . 23–7 . 2002 . 11901356 . 10.1097/00041444-200203000-00003 . 24222446 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. York JD, Veile RA, Donis-Keller H, Majerus PW . Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase . Proc Natl Acad Sci U S A . 90 . 12 . 5833–7 . Jul 1993 . 8390685 . 46817 . 10.1073/pnas.90.12.5833 . 1993PNAS...90.5833Y . free .
2. Web site: Entrez Gene: INPP1 inositol polyphosphate-1-phosphatase. 2012-07-31.