IMPDH2 explained
Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an enzyme that in humans is encoded by the IMPDH2 gene.[1] [2] [3]
Function
IMP dehydrogenase 2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. IMPDH2 catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate.[1] IMPDH2 has been identified as an intracellular target of the natural product sanglifehrin A.[4]
Clinical significance
This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.[1]
See also
Further reading
- Garat A, Cauffiez C, Hamdan-Khalil R, etal . IMPDH2 genetic polymorphism: a promoter single-nucleotide polymorphism disrupts a cyclic adenosine monophosphate responsive element . Genet Test Mol Biomarkers . 13 . 6 . 841–7 . 2009 . 19810816 . 10.1089/gtmb.2009.0096 .
- Wang J, Zeevi A, Webber S, etal . A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity . Pharmacogenet. Genomics . 17 . 4 . 283–90 . 2007 . 17496727 . 10.1097/FPC.0b013e328012b8cf . 21301713 .
- So HC, Fong PY, Chen RY, etal . Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population . Am. J. Med. Genet. B Neuropsychiatr. Genet. . 153B . 1 . 103–13 . 2010 . 19367581 . 10.1002/ajmg.b.30961 . 20522961 . 2019-09-28 . 2019-09-28 . https://web.archive.org/web/20190928055514/http://ir.psych.ac.cn/handle/311026/10097 . live .
- Grinyó J, Vanrenterghem Y, Nashan B . Association of four DNA polymorphisms with acute rejection after kidney transplantation . Transpl. Int. . 21 . 9 . 879–91 . 2008 . 18444945 . 10.1111/j.1432-2277.2008.00679.x . 42432512 . etal.
- Ohmann EL, Burckart GJ, Brooks MM, etal . Genetic polymorphisms influence mycophenolate mofetil-related adverse events in pediatric heart transplant patients . The Journal of Heart and Lung Transplantation . 29. 5. 509–516 . 2010 . 20061166 . 10.1016/j.healun.2009.11.602 .
- Sombogaard F, van Schaik RH, Mathot RA, etal . Interpatient variability in IMPDH activity in MMF-treated renal transplant patients is correlated with IMPDH type II 3757T > C polymorphism . Pharmacogenet. Genomics . 19 . 8 . 626–34 . 2009 . 19617864 . 10.1097/FPC.0b013e32832f5f1b . 41882586 .
- Fellenberg J, Bernd L, Delling G, etal . Prognostic significance of drug-regulated genes in high-grade osteosarcoma . Mod. Pathol. . 20 . 10 . 1085–94 . 2007 . 17660802 . 10.1038/modpathol.3800937 . free .
- Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
- He Y, Mou Z, Li W, etal . Identification of IMPDH2 as a tumor-associated antigen in colorectal cancer using immunoproteomics analysis . Int J Colorectal Dis . 24 . 11 . 1271–9 . 2009 . 19597826 . 10.1007/s00384-009-0759-2 . 24143679 .
- Peñuelas S, Noé V, Ciudad CJ . Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells . FEBS J. . 272 . 3 . 696–710 . 2005 . 15670151 . 10.1111/j.1742-4658.2004.04504.x . 43226077 . free .
- Winnicki W, Weigel G, Sunder-Plassmann G, etal . An inosine 5'-monophosphate dehydrogenase 2 single-nucleotide polymorphism impairs the effect of mycophenolic acid . Pharmacogenomics J. . 10 . 1 . 70–6 . 2010 . 19770842 . 10.1038/tpj.2009.43 . free .
- Patel CG, Richman K, Yang D, etal . Effect of diabetes mellitus on mycophenolate sodium pharmacokinetics and inosine monophosphate dehydrogenase activity in stable kidney transplant recipients . Ther Drug Monit . 29 . 6 . 735–42 . 2007 . 18043470 . 10.1097/FTD.0b013e31815d8ace . 4082794 .
- Sanquer S, Maison P, Tomkiewicz C, etal . Expression of inosine monophosphate dehydrogenase type I and type II after mycophenolate mofetil treatment: a 2-year follow-up in kidney transplantation . Clin. Pharmacol. Ther. . 83 . 2 . 328–35 . 2008 . 17713475 . 10.1038/sj.clpt.6100300 . 44919245 .
- Mohamed MF, Frye RF, Langaee TY . Interpopulation variation frequency of human inosine 5'-monophosphate dehydrogenase type II (IMPDH2) genetic polymorphisms . Genet. Test. . 12 . 4 . 513–6 . 2008 . 18976158 . 10.1089/gte.2008.0049 .
- Mannava S, Grachtchouk V, Wheeler LJ, etal . Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells . Cell Cycle . 7 . 15 . 2392–400 . 2008 . 18677108 . 10.4161/cc.6390. 3744895 .
- Chen L, Petrelli R, Olesiak M, etal . Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase . Bioorg. Med. Chem. . 16 . 15 . 7462–9 . 2008 . 18583139 . 10.1016/j.bmc.2008.06.003 .
- Guo D, Han J, Adam BL, etal . Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress . Biochem. Biophys. Res. Commun. . 337 . 4 . 1308–18 . 2005 . 16236267 . 10.1016/j.bbrc.2005.09.191 .
- Kudo M, Saito Y, Sasaki T, etal . Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals . Drug Metab. Pharmacokinet. . 24 . 6 . 557–64 . 2009 . 20045992 . 10.2133/dmpk.24.557.
- Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948.
Notes and References
- Web site: Entrez Gene: IMP (inosine monophosphate) dehydrogenase 2. 2017-10-29. 2024-04-22. https://web.archive.org/web/20240422065251/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3615. live.
- Natsumeda Y, Ohno S, Kawasaki H, Konno Y, Weber G, Suzuki K . Two distinct cDNAs for human IMP dehydrogenase . J. Biol. Chem. . 265 . 9 . 5292–5 . March 1990 . 10.1016/S0021-9258(19)34120-1 . 1969416 . free .
- Kost-Alimova MV, Glesne DA, Huberman E, Zelenin AV . Assignment1 of inosine '-monophosphate dehydrogenase type 2 (IMPDH2) to human chromosome band 3p21.2 by in situ hybridization . Cytogenet. Cell Genet. . 82 . 3–4 . 145–6 . 1998 . 9858805 . 10.1159/000015088 . 46764436 . 2019-07-05 . 2024-04-22 . https://web.archive.org/web/20240422065239/https://zenodo.org/records/1235297 . live .
- Pua KH, Stiles DT, Sowa ME, Verdine GL . IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex . Cell Rep. . 18 . 2 . 432–442 . 10 January 2017 . 28076787 . 10.1016/j.celrep.2016.12.030 . free .