LILRA4 explained

Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILR-A5) also known as CD85 antigen-like family member G (CD85g), and immunoglobulin-like transcript 7 (ILT-7) is a protein that in humans is encoded by the LILRA4 gene.^{[1] [2]}

This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a leukocyte immunoglobulin-like receptor gene cluster (LRC) at chromosomal region 19q13.4.

Further reading

• Cho M, Ishida K, Chen J, etal . SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production . Int. Immunol. . 20 . 1 . 155–64 . 2008 . 18048391 . 10.1093/intimm/dxm127 .
• Sellick GS, Wade R, Richards S, etal . Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis . Blood . 111 . 3 . 1625–33 . 2008 . 18006695 . 10.1182/blood-2007-08-110130 . free .
• Zhan X, Desiderio DM . Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry . Anal. Biochem. . 354 . 2 . 279–89 . 2006 . 16777052 . 10.1016/j.ab.2006.05.024 .
• Cao W, Rosen DB, Ito T, etal . Plasmacytoid dendritic cell–specific receptor ILT7–FcɛRIγ inhibits Toll-like receptor–induced interferon production . J. Exp. Med. . 203 . 6 . 1399–405 . 2006 . 16735691 . 10.1084/jem.20052454 . 2118323 .
• Ju XS, Hacker C, Scherer B, etal . Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation . Gene . 331 . 159–64 . 2004 . 15094202 . 10.1016/j.gene.2004.02.018 .
• Tedla N, Bandeira-Melo C, Tassinari P, etal . Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7 . Proc. Natl. Acad. Sci. U.S.A. . 100 . 3 . 1174–9 . 2003 . 12529506 . 10.1073/pnas.0337567100 . 298746 . 2003PNAS..100.1174T . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Rissoan MC, Duhen T, Bridon JM, etal . Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells . Blood . 100 . 9 . 3295–303 . 2002 . 12384430 . 10.1182/blood-2002-02-0638 . free .
• Young NT, Canavez F, Uhrberg M, etal . Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex . Immunogenetics . 53 . 4 . 270–8 . 2001 . 11491530 . 10.1007/s002510100332 . 2819935 .

Notes and References

1. Wende H, Volz A, Ziegler A . Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster . Immunogenetics . 51 . 8–9 . 703–13 . Sep 2000 . 10941842 . 10.1007/s002510000187 . 20719684 .
2. Web site: Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4.