ILKAP explained

Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.^[1]

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.

Interactions

ILKAP has been shown to interact with Integrin-linked kinase.^[2]

Further reading

• Tong Y, Quirion R, Shen SH . Cloning and characterization of a novel mammalian PP2C isozyme . The Journal of Biological Chemistry . 273 . 52 . 35282–90 . December 1998 . 9857069 . 10.1074/jbc.273.52.35282 . free .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Research . 11 . 3 . 422–35 . March 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE . Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1 . The EMBO Journal . 20 . 9 . 2160–70 . May 2001 . 11331582 . 125446 . 10.1093/emboj/20.9.2160 .
• Kumar AS, Naruszewicz I, Wang P, Leung-Hagesteijn C, Hannigan GE . ILKAP regulates ILK signaling and inhibits anchorage-independent growth . Oncogene . 23 . 19 . 3454–61 . April 2004 . 14990992 . 10.1038/sj.onc.1207473 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Web site: Entrez Gene: ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2C.
2. Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE . Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1 . The EMBO Journal . 20 . 9 . 2160–70 . May 2001 . 11331582 . 125446 . 10.1093/emboj/20.9.2160 .