IL3RA explained

Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a human gene.^[1]

Function

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y.^[1]

Interactions

IL3RA has been shown to interact with Interleukin 3.^{[2] [3]}

See also

• Cluster of differentiation

Further reading

• Hara T, Miyajima A . Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis . Stem Cells . 14 . 6 . 605–18 . 1996 . 8948019 . 10.1002/stem.140605 . 45074046 . free .
• Testa U, Riccioni R, Diverio D, Rossini A, Lo Coco F, Peschle C . Interleukin-3 receptor in acute leukemia . Leukemia . 18 . 2 . 219–26 . 2004 . 14671644 . 10.1038/sj.leu.2403224 . free .
• Kitamura T, Sato N, Arai K, Miyajima A . Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors . Cell . 66 . 6 . 1165–74 . 1991 . 1833064 . 10.1016/0092-8674(91)90039-2 . 42948973 .
• Machide M, Mano H, Todokoro K . Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain . Oncogene . 11 . 4 . 619–25 . 1995 . 7651724 .
• Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A . A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors . EMBO J. . 14 . 12 . 2816–26 . 1995 . 7796808 . 398400 . 10.1002/j.1460-2075.1995.tb07281.x.
• Kosugi H, Nakagawa Y, Hotta T, Saito H, Miyajima A, Arai K, Yokota T . Structure of the gene encoding the alpha subunit of the human interleukin 3 receptor . Biochem. Biophys. Res. Commun. . 208 . 1 . 360–7 . 1995 . 7887951 . 10.1006/bbrc.1995.1346 .
• Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF . Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF . EMBO J. . 13 . 21 . 5176–85 . 1994 . 7957082 . 395466 . 10.1002/j.1460-2075.1994.tb06848.x.
• Kremer E, Baker E, D'Andrea RJ, Slim R, Phillips H, Moretti PA, Lopez AF, Petit C, Vadas MA, Sutherland GR . Grant Robert Sutherland . A cytokine receptor gene cluster in the X-Y pseudoautosomal region? . Blood . 82 . 1 . 22–8 . 1993 . 8100720 . 10.1182/blood.V82.1.22.bloodjournal82122. free .
• Milatovich A, Kitamura T, Miyajima A, Francke U . Gene for the alpha-subunit of the human interleukin-3 receptor (IL3RA) localized to the X-Y pseudoautosomal region . Am. J. Hum. Genet. . 53 . 5 . 1146–53 . 1993 . 8213838 . 1682314 .
• Macardle PJ, Chen Z, Shih CY, Huang CM, Weedon H, Sun Q, Lopez AF, Zola H . Characterization of human leucocytes bearing the IL-3 receptor . Cell. Immunol. . 168 . 1 . 59–68 . 1996 . 8599840 . 10.1006/cimm.1996.0049 .
• Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF . Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding . Mol. Cell. Biol. . 16 . 6 . 3035–46 . 1996 . 8649415 . 231298 . 10.1128/MCB.16.6.3035.
• Bagley CJ, Phillips J, Cambareri B, Vadas MA, Lopez AF . A discontinuous eight-amino acid epitope in human interleukin-3 binds the alpha-chain of its receptor . J. Biol. Chem. . 271 . 50 . 31922–8 . 1996 . 8943237 . 10.1074/jbc.271.50.31922 . free .
• Klein BK, Feng Y, McWherter CA, Hood WF, Paik K, McKearn JP . The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling . J. Biol. Chem. . 272 . 36 . 22630–41 . 1997 . 9278420 . 10.1074/jbc.272.36.22630 . free .
• Wang P, Wu P, Cheewatrakoolpong B, Myers JG, Egan RW, Billah MM . Selective inhibition of IL-5 receptor alpha-chain gene transcription by IL-5, IL-3, and granulocyte-macrophage colony-stimulating factor in human blood eosinophils . J. Immunol. . 160 . 9 . 4427–32 . 1998 . 10.4049/jimmunol.160.9.4427 . 9574547 .
• Res PC, Couwenberg F, Vyth-Dreese FA, Spits H . Expression of pTalpha mRNA in a committed dendritic cell precursor in the human thymus . Blood . 94 . 8 . 2647–57 . 1999 . 10515868 . 10.1182/blood.V94.8.2647.420k06_2647_2657. 36813728 .
• Jahnsen FL, Lund-Johansen F, Dunne JF, Farkas L, Haye R, Brandtzaeg P . Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy . J. Immunol. . 165 . 7 . 4062–8 . 2000 . 11034417 . 10.4049/jimmunol.165.7.4062 . free .
• Heinemann A, Hartnell A, Stubbs VE, Murakami K, Soler D, LaRosa G, Askenase PW, Williams TJ, Sabroe I . Basophil responses to chemokines are regulated by both sequential and cooperative receptor signaling . J. Immunol. . 165 . 12 . 7224–33 . 2000 . 11120855 . 10.4049/jimmunol.165.12.7224 . free .
• Carr PD, Gustin SE, Church AP, Murphy JM, Ford SC, Mann DA, Woltring DM, Walker I, Ollis DL, Young IG . Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration . Cell . 104 . 2 . 291–300 . 2001 . 11207369 . 10.1016/S0092-8674(01)00213-6 . 14494146 . free .
• Kunitani H, Shimizu Y, Murata H, Higuchi K, Watanabe A . Phenotypic analysis of circulating and intrahepatic dendritic cell subsets in patients with chronic liver diseases . J. Hepatol. . 36 . 6 . 734–41 . 2002 . 12044522 . 10.1016/S0168-8278(02)00062-4 .

Notes and References

1. Web site: Entrez Gene: IL3RA interleukin 3 receptor, alpha (low affinity).
2. Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF . Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding . Mol. Cell. Biol. . 16 . 6 . 3035–46 . June 1996 . 8649415 . 231298 . 10.1128/MCB.16.6.3035 .
3. Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF . Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF . EMBO J. . 13 . 21 . 5176–85 . November 1994 . 7957082 . 395466 . 10.1002/j.1460-2075.1994.tb06848.x .