IL31RA explained

Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene.^{[1] [2] [3]}

IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004).[supplied by OMIM]^[4]

Further reading

• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Diveu C, Lelièvre E, Perret D, etal . GPL, a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor. . J. Biol. Chem. . 278 . 50 . 49850–9 . 2004 . 14504285 . 10.1074/jbc.M307286200 . free .
• Dreuw A, Radtke S, Pflanz S, etal . Characterization of the signaling capacities of the novel gp130-like cytokine receptor. . J. Biol. Chem. . 279 . 34 . 36112–20 . 2005 . 15194700 . 10.1074/jbc.M401122200 . free .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites. . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Diveu C, Lak-Hal AH, Froger J, etal . Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling. . Eur. Cytokine Netw. . 15 . 4 . 291–302 . 2005 . 15627637 .
• Bilsborough J, Leung DY, Maurer M, etal . IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. . J. Allergy Clin. Immunol. . 117 . 2 . 418–25 . 2006 . 16461143 . 10.1016/j.jaci.2005.10.046 . free .

Notes and References

1. Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA . Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice . Nat Immunol . 5 . 7 . 752–60 . Jun 2004 . 15184896 . 10.1038/ni1084 . 12442845 .
2. Ghilardi N, Li J, Hongo JA, Yi S, Gurney A, de Sauvage FJ . A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5 . J Biol Chem . 277 . 19 . 16831–6 . May 2002 . 11877449 . 10.1074/jbc.M201140200 . free .
3. Web site: Entrez Gene: IL31RA interleukin 31 receptor A.
4. Web site: Entrez Gene: IL31RA interleukin 31 receptor A.