Interleukin 27 receptor, alpha subunit explained

Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene.^[1]

Function

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.^[1]

Interactions

Interleukin 27 receptor, alpha subunit has been shown to interact with STAT1.^[2]

Further reading

• Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T, Whitmore TE, O'Hara PJ, Foster DF . Cloning and characterization of a novel class I cytokine receptor. . Biochem. Biophys. Res. Commun. . 246 . 1 . 82–90 . 1998 . 9600072 . 10.1006/bbrc.1998.8576 .
• Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ . Development of Th1-type immune responses requires the type I cytokine receptor TCCR. . Nature . 407 . 6806 . 916–20 . 2000 . 11057672 . 10.1038/35038103 . 2000Natur.407..916C . 205009928 .
• Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA . IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. . Immunity . 16 . 6 . 779–90 . 2002 . 12121660 . 10.1016/S1074-7613(02)00324-2 . free .
• Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H . Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. . J. Immunol. . 170 . 10 . 4886–90 . 2003 . 12734330 . 10.4049/jimmunol.170.10.4886 . free .
• Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA . WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. . J. Immunol. . 172 . 4 . 2225–31 . 2004 . 14764690 . 10.4049/jimmunol.172.4.2225 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . Huda Zoghbi.
• Pradhan A, Lambert QT, Reuther GW . Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor. . Proc. Natl. Acad. Sci. U.S.A. . 104 . 47 . 18502–7 . 2008 . 18003935 . 2141806 . 10.1073/pnas.0702388104 . free .

Notes and References

1. Web site: Entrez Gene: IL27RA interleukin 27 receptor, alpha.
2. Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H . Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment . J. Immunol. . 170 . 10 . 4886–90 . May 2003 . 12734330 . 10.4049/jimmunol.170.10.4886 . free .