IL22RA1 explained

Interleukin 22 receptor, alpha 1 is a protein that in humans is encoded by the IL22RA1 gene.^[1]

Function

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10RB/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36.

Further reading

• Bleicher L, de Moura PR, Watanabe L, Colau D, Dumoutier L, Renauld JC, Polikarpov I . Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism . FEBS Letters . 582 . 20 . 2985–92 . September 2008 . 18675809 . 10.1016/j.febslet.2008.07.046 . 20952148 .
• Jones BC, Logsdon NJ, Walter MR . Structure of IL-22 bound to its high-affinity IL-22R1 chain . Structure . 16 . 9 . 1333–44 . September 2008 . 18599299 . 2637415 . 10.1016/j.str.2008.06.005 .
• de Moura PR, Watanabe L, Bleicher L, Colau D, Dumoutier L, Lemaire MM, Renauld JC, Polikarpov I . Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22 . FEBS Letters . 583 . 7 . 1072–7 . April 2009 . 19285080 . 10.1016/j.febslet.2009.03.006 . free .
• Dumoutier L, de Meester C, Tavernier J, Renauld JC . New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain . The Journal of Biological Chemistry . 284 . 39 . 26377–84 . September 2009 . 19632985 . 2785325 . 10.1074/jbc.M109.007955 . free .
• Wu PW, Li J, Kodangattil SR, Luxenberg DP, Bennett F, Martino M, Collins M, Dunussi-Joannopoulos K, Gill DS, Wolfman NM, Fouser LA . IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22 . Journal of Molecular Biology . 382 . 5 . 1168–83 . October 2008 . 18675824 . 10.1016/j.jmb.2008.07.046 .
• Meng S, Gui Q, Xu Q, Lu K, Jiao X, Fan J, Ge B, Ke Y, Zhang S, Wu J, Wang C . Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation . Journal of Molecular Cell Biology . 2 . 4 . 223–30 . August 2010 . 20671117 . 2948820 . 10.1093/jmcb/mjq017 .
• Kotenko SV, Izotova LS, Mirochnitchenko OV, Esterova E, Dickensheets H, Donnelly RP, Pestka S . Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes . The Journal of Biological Chemistry . 276 . 4 . 2725–32 . January 2001 . 11035029 . 10.1074/jbc.M007837200 . free .
• Chang Y, Al-Alwan L, Risse PA, Halayko AJ, Martin JG, Baglole CJ, Eidelman DH, Hamid Q . Th17-associated cytokines promote human airway smooth muscle cell proliferation . FASEB Journal . 26 . 12 . 5152–60 . December 2012 . 22898922 . 10.1096/fj.12-208033 . free . 205369384 .
• Shioya M, Andoh A, Kakinoki S, Nishida A, Fujiyama Y . Interleukin 22 receptor 1 expression in pancreas islets . Pancreas . 36 . 2 . 197–9 . March 2008 . 18376313 . 10.1097/MPA.0b013e3181594258 . 26713011 .

Notes and References

1. Web site: Entrez Gene: Interleukin 22 receptor, alpha 1 .