Interleukin 1 receptor, type I explained

Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.^[1]

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.^[1]

Interactions

Interleukin 1 receptor, type I has been shown to interact with PIK3R1,^[2] Myd88^{[3] [4]} and IL1RAP.^[5]

See also

• Cluster of differentiation
• Interleukin 1 receptor, type II

Further reading

• Copeland NG, Silan CM, Kingsley DM, etal . Chromosomal location of murine and human IL-1 receptor genes. . Genomics . 9 . 1 . 44–50 . 1991 . 1672292 . 10.1016/0888-7543(91)90219-5 .
• McMahan CJ, Slack JL, Mosley B, etal . A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. . EMBO J. . 10 . 10 . 2821–32 . 1991 . 1833184 . 10.1002/j.1460-2075.1991.tb07831.x. 452992 .
• Uhl J, Newton RC, Giri JG, etal . Identification of IL-1 receptors on human monocytes. . J. Immunol. . 142 . 5 . 1576–81 . 1989 . 10.4049/jimmunol.142.5.1576 . 2521881 . 28462235 . free .
• Sims JE, Acres RB, Grubin CE, etal . Cloning the interleukin 1 receptor from human T cells. . Proc. Natl. Acad. Sci. U.S.A. . 86 . 22 . 8946–50 . 1989 . 2530587 . 10.1073/pnas.86.22.8946 . 298407 . 1989PNAS...86.8946S . free .
• Chua AO, Gubler U . Sequence of the cDNA for the human fibroblast type interleukin-1 receptor. . Nucleic Acids Res. . 17 . 23 . 10114 . 1990 . 2532321 . 10.1093/nar/17.23.10114 . 335251 .
• Dower SK, Kronheim SR, Hopp TP, etal . The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical. . Nature . 324 . 6094 . 266–8 . 1987 . 2946959 . 10.1038/324266a0 . 1986Natur.324..266D . 4233242 .
• Rautonen N, Rautonen J, Martin NL, Wara DW . HIV-1 Tat induces cytokine synthesis by uninfected mononuclear cells. . AIDS . 8 . 10 . 1504–6 . 1995 . 7818827 . 10.1097/00002030-199410000-00023 .
• Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ . Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta. . Nature . 386 . 6621 . 190–4 . 1997 . 9062193 . 10.1038/386190a0 . 1997Natur.386..190V . 4358379 .
• Schreuder H, Tardif C, Trump-Kallmeyer S, etal . A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist. . Nature . 386 . 6621 . 194–200 . 1997 . 9062194 . 10.1038/386194a0 . 1997Natur.386..194S . 4266953 .
• Rameshwar P, Poddar A, Zhu G, Gascón P . Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts. . J. Immunol. . 158 . 7 . 3417–24 . 1997 . 10.4049/jimmunol.158.7.3417 . 9120302 . 24164798 . free .
• Reddy SA, Huang JH, Liao WS . Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation. . J. Biol. Chem. . 272 . 46 . 29167–73 . 1997 . 9360994 . 10.1074/jbc.272.46.29167 . free .
• Huang J, Gao X, Li S, Cao Z . Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. . Proc. Natl. Acad. Sci. U.S.A. . 94 . 24 . 12829–32 . 1998 . 9371760 . 10.1073/pnas.94.24.12829 . 24223 . 1997PNAS...9412829H . free .
• Muzio M, Ni J, Feng P, Dixit VM . IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. . Science . 278 . 5343 . 1612–5 . 1997 . 9374458 . 10.1126/science.278.5343.1612 . 1997Sci...278.1612M .
• Dale M, Nicklin MJ . Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. . Genomics . 57 . 1 . 177–9 . 1999 . 10191101 . 10.1006/geno.1999.5767 .
• Sizemore N, Leung S, Stark GR . Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. . Mol. Cell. Biol. . 19 . 7 . 4798–805 . 1999 . 10373529 . 10.1128/mcb.19.7.4798. 84278 .
• Burns K, Clatworthy J, Martin L, etal . Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. . Nat. Cell Biol. . 2 . 6 . 346–51 . 2000 . 10854325 . 10.1038/35014038 . 32036101 .
• Vigers GP, Dripps DJ, Edwards CK, Brandhuber BJ . X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1. . J. Biol. Chem. . 275 . 47 . 36927–33 . 2001 . 10903327 . 10.1074/jbc.M006071200 . free .
• Lin H, Ho AS, Haley-Vicente D, etal . Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. . J. Biol. Chem. . 276 . 23 . 20597–602 . 2001 . 11278614 . 10.1074/jbc.M010095200 . free .
• Joos L, McIntyre L, Ruan J, etal . Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers. . Thorax . 56 . 11 . 863–6 . 2001 . 11641511 . 10.1136/thorax.56.11.863 . 1745962 .
• Köller M, Kutscha-Lissberg F, Brom J, etal . Influence of low molecular weight heparin (certoparin) and unfractionated heparin on the release of cytokines from human leukocytes. . Inflammation . 25 . 5 . 331–7 . 2003 . 11820460 . 10.1023/A:1012883916991 . 21831719 .

Notes and References

1. Web site: Entrez Gene: IL1R1 interleukin 1 receptor, type I.
2. 10.1074/jbc.272.46.29167 . Reddy . S A . Huang J H . Liao W S . November 1997 . Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation . J. Biol. Chem. . 272 . 46 . 29167–73 . UNITED STATES. 0021-9258. 9360994 . free .
3. Burns . K . Clatworthy J . Martin L . Martinon F . Plumpton C . Maschera B . Lewis A . Ray K . Tschopp J . Volpe F . June 2000 . Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor . Nat. Cell Biol. . 2 . 6 . 346–51 . ENGLAND. 1465-7392. 10854325 . 10.1038/35014038 . 32036101 .
4. 10.1126/science.278.5343.1612 . Muzio . M . Ni J . Feng P . Dixit V M . November 1997 . IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling . . 278 . 5343 . 1612–5 . UNITED STATES. 0036-8075. 9374458 . 1997Sci...278.1612M .
5. 10.1073/pnas.94.24.12829 . Huang . J . Gao X . Li S . Cao Z . November 1997 . Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein . . 94 . 24 . 12829–32 . UNITED STATES. 0027-8424. 9371760 . 1997PNAS...9412829H . 24223 . free .