IL1RAP explained

Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene.^{[1] [2] [3]}

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.

Interactions

IL1RAP has been shown to interact with TOLLIP^[4] and Interleukin 1 receptor, type I.^[5]

Further reading

• Greenfeder SA, Nunes P, Kwee L, etal . Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex . J. Biol. Chem. . 270 . 23 . 13757–65 . 1995 . 7775431 . 10.1074/jbc.270.23.13757 . free .
• Parnet P, Garka KE, Bonnert TP, etal . IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP . J. Biol. Chem. . 271 . 8 . 3967–70 . 1996 . 8626725 . 10.1074/jbc.271.8.3967 . free .
• Huang J, Gao X, Li S, Cao Z . Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein . Proc. Natl. Acad. Sci. U.S.A. . 94 . 24 . 12829–32 . 1998 . 9371760 . 10.1073/pnas.94.24.12829 . 24223 . 1997PNAS...9412829H . free .
• Cullinan EB, Kwee L, Nunes P, etal . IL-1 receptor accessory protein is an essential component of the IL-1 receptor . J. Immunol. . 161 . 10 . 5614–20 . 1998 . 10.4049/jimmunol.161.10.5614 . 9820540 . 22101221 . free .
• Lang D, Knop J, Wesche H, etal . The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness . J. Immunol. . 161 . 12 . 6871–7 . 1999 . 10.4049/jimmunol.161.12.6871 . 9862719 . 8940186 . free .
• Morton NM, de Groot RP, Cawthorne MA, Emilsson V . Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells . FEBS Lett. . 442 . 1 . 57–60 . 1999 . 9923604 . 10.1016/S0014-5793(98)01623-8 . 81592992 .
• Sizemore N, Leung S, Stark GR . Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit . Mol. Cell. Biol. . 19 . 7 . 4798–805 . 1999 . 10373529 . 10.1128/mcb.19.7.4798. 84278 .
• Jensen LE, Muzio M, Mantovani A, Whitehead AS . IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein . J. Immunol. . 164 . 10 . 5277–86 . 2000 . 10799889 . 10.4049/jimmunol.164.10.5277. free .
• Burns K, Clatworthy J, Martin L, etal . Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor . Nat. Cell Biol. . 2 . 6 . 346–51 . 2000 . 10854325 . 10.1038/35014038 . 32036101 .
• Bigonnesse F, Marois M, Maheux R, Akoum A . Interleukin-1 receptor accessory protein is constitutively expressed in human endometrium throughout the menstrual cycle . Mol. Hum. Reprod. . 7 . 4 . 333–9 . 2001 . 11279295 . 10.1093/molehr/7.4.333 . free .
• Jefferies C, Bowie A, Brady G, etal . Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1 . Mol. Cell. Biol. . 21 . 14 . 4544–52 . 2001 . 11416133 . 10.1128/MCB.21.14.4544-4552.2001 . 87113 .
• Radons J, Gabler S, Wesche H, etal . Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling . J. Biol. Chem. . 277 . 19 . 16456–63 . 2002 . 11880380 . 10.1074/jbc.M201000200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ruhul Amin AR, Machida K, Oshima K, etal . A role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent signaling . Oncogene . 21 . 57 . 8871–8 . 2003 . 12483539 . 10.1038/sj.onc.1206018 . 29228572 .
• Smith DE . Hanna R . Della Friend . The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action . Immunity . 18 . 1 . 87–96 . 2003 . 12530978 . 10.1016/S1074-7613(02)00514-9 . etal. free .
• Boch JA, Yoshida Y, Koyama Y, etal . Characterization of a cascade of protein interactions initiated at the IL-1 receptor . Biochem. Biophys. Res. Commun. . 303 . 2 . 525–31 . 2003 . 12659850 . 10.1016/S0006-291X(03)00385-1 .
• Bin LH, Xu LG, Shu HB . TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling . J. Biol. Chem. . 278 . 27 . 24526–32 . 2003 . 12721283 . 10.1074/jbc.M303451200 . free .
• Jensen LE, Whitehead AS . Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis . Cell. Signal. . 15 . 8 . 793–802 . 2004 . 12781872 . 10.1016/S0898-6568(03)00039-1 .

Notes and References

1. Dale M, Hammond DW, Cox A, Nicklin MJ . The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping . Genomics . 47 . 2 . 325–6 . April 1998 . 9479509 . 10.1006/geno.1997.5113 .
2. Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU . The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases) . J Biol Chem . 272 . 12 . 7727–31 . April 1997 . 9065432 . 10.1074/jbc.272.12.7727 . free .
3. Web site: Entrez Gene: IL1RAP interleukin 1 receptor accessory protein.
4. Burns . K . Clatworthy J . Martin L . Martinon F . Plumpton C . Maschera B . Lewis A . Ray K . Tschopp J . Volpe F . June 2000 . Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor . Nat. Cell Biol. . 2 . 6 . 346–51 . ENGLAND. 1465-7392. 10854325 . 10.1038/35014038 . 32036101 .
5. Huang . J . Gao X . Li S . Cao Z . November 1997 . Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein . . 94 . 24 . 12829–32 . UNITED STATES. 0027-8424. 9371760 . 1997PNAS...9412829H . 10.1073/pnas.94.24.12829 . 24223 . free .