IL18RAP explained

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene.^{[1] [2]}

Function

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18.^[1]

Disease association

Variants at IL18RAP have been linked to susceptibility to Coeliac disease.^[3]

See also

• Interleukin-18 receptor

Further reading

• Born TL, Thomassen E, Bird TA, Sims JE . Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling . J. Biol. Chem. . 273 . 45 . 29445–50 . 1998 . 9792649 . 10.1074/jbc.273.45.29445 . free .
• Sareneva T, Julkunen I, Matikainen S . IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells . J. Immunol. . 165 . 4 . 1933–8 . 2000 . 10925275 . 10.4049/jimmunol.165.4.1933. free .
• Mee JB, Alam Y, Groves RW . Human keratinocytes constitutively produce but do not process interleukin-18 . Br. J. Dermatol. . 143 . 2 . 330–6 . 2000 . 10951141 . 10.1046/j.1365-2133.2000.03759.x . 44747360 .
• Debets R, Timans JC, Churakowa T, etal . IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18 . J. Immunol. . 165 . 9 . 4950–6 . 2000 . 11046021 . 10.4049/jimmunol.165.9.4950. free .
• Salvati VM, MacDonald TT, Bajaj-Elliott M, etal . Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease . Gut . 50 . 2 . 186–90 . 2002 . 11788557 . 10.1136/gut.50.2.186 . 1773110 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Fukushima K, Ikehara Y, Yamashita K . Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production . J. Biol. Chem. . 280 . 18 . 18056–62 . 2005 . 15760905 . 10.1074/jbc.M413297200 . free .
• Hillier LW, Graves TA, Fulton RS, etal . Generation and annotation of the DNA sequences of human chromosomes 2 and 4 . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . free .
• Fiszer D, Rozwadowska N, Rychlewski L, etal . Identification of IL-18RAP mRNA truncated splice variants in human testis and the other human tissues . Cytokine . 39 . 3 . 178–83 . 2008 . 17897836 . 10.1016/j.cyto.2007.07.186 .

Notes and References

1. Web site: Entrez Gene: IL18RAP interleukin 18 receptor accessory protein.
2. Born TL, Thomassen E, Bird TA, Sims JE . Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling . J. Biol. Chem. . 273 . 45 . 29445–50 . November 1998 . 9792649 . 10.1074/jbc.273.45.29445 . free .
3. Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA . Novel celiac disease genetic determinants related to the immune response . Nat. Genet. . 40 . 4 . 395–402 . April 2008 . 18311140 . 10.1038/ng.102 . 2673512 .