IL17RB explained

Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene.^{[1] [2] [3]}

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.

See also

• Interleukin-17 receptor

Further reading

• Schwandner R, Yamaguchi K, Cao Z . Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction. . J. Exp. Med. . 191 . 7 . 1233–40 . 2000 . 10748240 . 10.1084/jem.191.7.1233 . 2193168 .
• Lee J, Ho WH, Maruoka M, etal . IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. . J. Biol. Chem. . 276 . 2 . 1660–4 . 2001 . 11058597 . 10.1074/jbc.M008289200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Hillman RT, Green RE, Brenner SE . An unappreciated role for RNA surveillance. . Genome Biol. . 5 . 2 . R8 . 2005 . 14759258 . 10.1186/gb-2004-5-2-r8 . 395752 . free .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites. . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Symmans WF . Genomic testing for sensitivity of breast cancer to hormonal therapy. . Clin. Cancer Res. . 12 . 7 Pt 1 . 1954–5 . 2006 . 16609001 . 10.1158/1078-0432.CCR-06-0289 . free .
• Goetz MP, Suman VJ, Ingle JN, etal . A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen. . Clin. Cancer Res. . 12 . 7 Pt 1 . 2080–7 . 2006 . 16609019 . 10.1158/1078-0432.CCR-05-1263 . 9930864 .
• Ma XJ, Hilsenbeck SG, Wang W, etal . The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer. . J. Clin. Oncol. . 24 . 28 . 4611–9 . 2006 . 17008703 . 10.1200/JCO.2006.06.6944 . free .

Notes and References

1. Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R . A novel cytokine receptor-ligand pair. Identification, molecular Aaron 9 ok ò charkacterization, and in vivo immunomodulatory activity . J Biol Chem . 275 . 25 . 19167–76 . Aug 2000 . 10749887 . 10.1074/jbc.M910228199 . free .
2. Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, ((Shaughnessy JD Jr)) . Evi27 encodes a novel membrane protein with homology to the IL17 receptor . Oncogene . 19 . 17 . 2098–109 . Jun 2000 . 10815801 . 10.1038/sj.onc.1203577 . 27521628 .
3. Web site: Entrez Gene: IL17RB interleukin 17 receptor B.