IL17RA explained

Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene.^[1]

Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.

See also

• Interleukin-17 receptor

Further reading

• Yao Z, Spriggs MK, Derry JM, etal . Molecular characterization of the human interleukin (IL)-17 receptor . Cytokine . 9 . 11 . 794–800 . 1998 . 9367539 . 10.1006/cyto.1997.0240 .
• Dunham I, Shimizu N, Roe BA, etal . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Honorati MC, Meliconi R, Pulsatelli L, etal . High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients . Rheumatology (Oxford) . 40 . 5 . 522–7 . 2001 . 11371660 . 10.1093/rheumatology/40.5.522 . free .
• Footz TK, Brinkman-Mills P, Banting GS, etal . Analysis of the Cat Eye Syndrome Critical Region in Humans and the Region of Conserved Synteny in Mice: A Search for Candidate Genes at or near the Human Chromosome 22 Pericentromere . Genome Res. . 11 . 6 . 1053–70 . 2001 . 11381032 . 10.1101/gr.154901 . 311098 .
• Haudenschild D, Moseley T, Rose L, Reddi AH . Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer . J. Biol. Chem. . 277 . 6 . 4309–16 . 2002 . 11706037 . 10.1074/jbc.M109372200 . free .
• Kehlen A, Thiele K, Riemann D, Langner J . Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis . Clin. Exp. Immunol. . 127 . 3 . 539–46 . 2002 . 11966773 . 10.1046/j.1365-2249.2002.01782.x . 1906300 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Steiner GE, Newman ME, Paikl D, etal . Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate . Prostate . 56 . 3 . 171–82 . 2003 . 12772186 . 10.1002/pros.10238 . 34604221 .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• McAllister F, Henry A, Kreindler JL, etal . Role of IL-17A, IL-17F, and the IL-17 Receptor in Regulating Growth-Related Oncogene-α and Granulocyte Colony-Stimulating Factor in Bronchial Epithelium: Implications for Airway Inflammation in Cystic Fibrosis . J. Immunol. . 175 . 1 . 404–12 . 2005 . 15972674 . 10.4049/jimmunol.175.1.404. 2849297 .
• Pongcharoen S, Niumsup P, Sanguansermsri D, etal . The effect of interleukin-17 on the proliferation and invasion of JEG-3 human choriocarcinoma cells . Am. J. Reprod. Immunol. . 55 . 4 . 291–300 . 2006 . 16533341 . 10.1111/j.1600-0897.2006.00366.x . 35458245 .
• Toy D, Kugler D, Wolfson M, etal . Cutting edge: interleukin 17 signals through a heteromeric receptor complex . J. Immunol. . 177 . 1 . 36–9 . 2006 . 16785495 . 10.4049/jimmunol.177.1.36. free .
• Wang X, Dong Z, Zhu DD, Guan B . Expression profile of immune-associated genes in nasal polyps . Ann. Otol. Rhinol. Laryngol. . 115 . 6 . 450–6 . 2006 . 16805377 . 10.1177/000348940611500609. 20528405 .
• Rong Z, Cheng L, Ren Y, etal . Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6 . Cell. Signal. . 19 . 7 . 1514–20 . 2007 . 17346928 . 10.1016/j.cellsig.2007.01.025 .
• Maitra A, Shen F, Hanel W, etal . Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression . Proc. Natl. Acad. Sci. U.S.A. . 104 . 18 . 7506–11 . 2007 . 17456598 . 10.1073/pnas.0611589104 . 1863505 . 2007PNAS..104.7506M . free .

Notes and References

1. Web site: Entrez Gene: IL17RA interleukin 17 receptor A.