IL36B explained

Interleukin-36 beta also known as interleukin-1 family member 8 (IL1F8) is a protein that in humans is encoded by the IL36B gene.^{[1] [2] [3] [4]}

Function

The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.

Further reading

• Nicklin MJ, Weith A, Duff GW . A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes . Genomics . 19 . 2 . 382–4 . 1994 . 8188271 . 10.1006/geno.1994.1076 .
• Nothwang HG, Strahm B, Denich D, etal . Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13 . Genomics . 41 . 3 . 370–8 . 1997 . 9169134 . 10.1006/geno.1997.4654 .
• Kumar S, McDonnell PC, Lehr R, etal . Identification and initial characterization of four novel members of the interleukin-1 family . J. Biol. Chem. . 275 . 14 . 10308–14 . 2000 . 10744718 . 10.1074/jbc.275.14.10308 . free .
• Busfield SJ, Comrack CA, Yu G, etal . Identification and gene organization of three novel members of the IL-1 family on human chromosome 2 . Genomics . 66 . 2 . 213–6 . 2000 . 10860666 . 10.1006/geno.2000.6184 .
• Barton JL, Herbst R, Bosisio D, etal . A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities . Eur. J. Immunol. . 30 . 11 . 3299–308 . 2001 . 11093146 . 10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S . free .
• Pan G, Risser P, Mao W, etal . IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp . Cytokine . 13 . 1 . 1–7 . 2001 . 11145836 . 10.1006/cyto.2000.0799 .
• Lin H, Ho AS, Haley-Vicente D, etal . Cloning and characterization of IL-1HY2, a novel interleukin-1 family member . J. Biol. Chem. . 276 . 23 . 20597–602 . 2001 . 11278614 . 10.1074/jbc.M010095200 . free .
• Debets R, Timans JC, Homey B, etal . Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2 . J. Immunol. . 167 . 3 . 1440–6 . 2001 . 11466363 . 10.4049/jimmunol.167.3.1440. 85986577 .
• Sims JE, Nicklin MJ, Bazan JF, etal . A new nomenclature for IL-1-family genes . Trends Immunol. . 22 . 10 . 536–7 . 2001 . 11574262 . 10.1016/S1471-4906(01)02040-3 .
• Nicklin MJ, Barton JL, Nguyen M, etal . A sequence-based map of the nine genes of the human interleukin-1 cluster . Genomics . 79 . 5 . 718–25 . 2002 . 11991722 . 10.1006/geno.2002.6751 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Towne JE, Garka KE, Renshaw BR, etal . Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs . J. Biol. Chem. . 279 . 14 . 13677–88 . 2004 . 14734551 . 10.1074/jbc.M400117200 . free .
• Hillier LW, Graves TA, Fulton RS, etal . Generation and annotation of the DNA sequences of human chromosomes 2 and 4 . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . free .

Notes and References

1. Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE . Four new members expand the interleukin-1 superfamily . J Biol Chem . 275 . 2 . 1169–75 . Feb 2000 . 10625660 . 10.1074/jbc.275.2.1169 . free.
2. Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE . IL1HY1: A novel interleukin-1 receptor antagonist gene . Biochem Biophys Res Commun . 263 . 3 . 702–6 . Nov 1999 . 10512743 . 10.1006/bbrc.1999.1440 .
3. Magne D, Palmer G, Barton JL, Mezin F, Talabot-Ayer D, Bas S, Duffy T, Noger M, Guerne PA, Nicklin MJ, Gabay C . The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes . . 8 . 3 . R80 . Jun 2006 . 16646978 . 1526623 . 10.1186/ar1946 . free .
4. Web site: Entrez Gene: IL1F8 interleukin 1 family, member 8 (eta).