IL1RL2 explained

Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene.^{[1] [2] [3] [4]}

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.

Further reading

• McMahan CJ, Slack JL, Mosley B, etal . A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. . EMBO J. . 10 . 10 . 2821–32 . 1991 . 1833184 . 10.1002/j.1460-2075.1991.tb07831.x. 452992 .
• Colotta F, Re F, Muzio M, etal . Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. . Science . 261 . 5120 . 472–5 . 1993 . 8332913 . 10.1126/science.8332913 . 1993Sci...261..472C .
• Torigoe K, Ushio S, Okura T, etal . Purification and characterization of the human interleukin-18 receptor. . J. Biol. Chem. . 272 . 41 . 25737–42 . 1997 . 9325300 . 10.1074/jbc.272.41.25737 . free .
• Born TL, Smith DE, Garka KE, etal . Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling. . J. Biol. Chem. . 275 . 39 . 29946–54 . 2000 . 10882729 . 10.1074/jbc.M004077200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ozkara C, Uzan M, Tanriverdi T, etal . Lack of association between IL-1beta/alpha gene polymorphisms and temporal lobe epilepsy with hippocampal sclerosis. . Seizure: The Journal of the British Epilepsy Association . 15 . 5 . 288–91 . 2006 . 16546408 . 10.1016/j.seizure.2006.02.016 . free .

Notes and References

1. Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, Clevenger W, Oltersdorf T, De Souza EB, Maki RA . Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2) . J Neuroimmunol . 70 . 2 . 113–22 . Dec 1996 . 8898719 . 10.1016/S0165-5728(96)00047-1 . 53171191 .
2. Dale M, Nicklin MJ . Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q . Genomics . 57 . 1 . 177–9 . Jun 1999 . 10191101 . 10.1006/geno.1999.5767 .
3. Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA . Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2 . Journal of Immunology . 167 . 3 . 1440–6 . Jul 2001 . 11466363 . 10.4049/jimmunol.167.3.1440. free .
4. Web site: Entrez Gene: IL1RL2 interleukin 1 receptor-like 2.