IL1F10 explained

Interleukin-1 family member 10 is a protein that in humans is encoded by the IL1F10 gene.^{[1] [2] [3] [4]}

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported.

Further reading

• Nicklin MJ, Weith A, Duff GW . A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. . Genomics . 19 . 2 . 382–4 . 1994 . 8188271 . 10.1006/geno.1994.1076 .
• Nothwang HG, Strahm B, Denich D, etal . Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13. . Genomics . 41 . 3 . 370–8 . 1997 . 9169134 . 10.1006/geno.1997.4654 .
• Mulero JJ, Pace AM, Nelken ST, etal . IL1HY1: A novel interleukin-1 receptor antagonist gene. . Biochem. Biophys. Res. Commun. . 263 . 3 . 702–6 . 1999 . 10512743 . 10.1006/bbrc.1999.1440 .
• Smith DE, Renshaw BR, Ketchem RR, etal . Four new members expand the interleukin-1 superfamily. . J. Biol. Chem. . 275 . 2 . 1169–75 . 2000 . 10625660 . 10.1074/jbc.275.2.1169 . free .
• Kumar S, McDonnell PC, Lehr R, etal . Identification and initial characterization of four novel members of the interleukin-1 family. . J. Biol. Chem. . 275 . 14 . 10308–14 . 2000 . 10744718 . 10.1074/jbc.275.14.10308 . free .
• Busfield SJ, Comrack CA, Yu G, etal . Identification and gene organization of three novel members of the IL-1 family on human chromosome 2. . Genomics . 66 . 2 . 213–6 . 2000 . 10860666 . 10.1006/geno.2000.6184 .
• Barton JL, Herbst R, Bosisio D, etal . A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities. . Eur. J. Immunol. . 30 . 11 . 3299–308 . 2001 . 11093146 . 10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S . free .
• Pan G, Risser P, Mao W, etal . IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp. . Cytokine . 13 . 1 . 1–7 . 2001 . 11145836 . 10.1006/cyto.2000.0799 .
• Lin H, Ho AS, Haley-Vicente D, etal . Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. . J. Biol. Chem. . 276 . 23 . 20597–602 . 2001 . 11278614 . 10.1074/jbc.M010095200 . free .
• Debets R, Timans JC, Homey B, etal . Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. . Journal of Immunology . 167 . 3 . 1440–6 . 2001 . 11466363 . 10.4049/jimmunol.167.3.1440. 85986577 .
• Sims JE, Nicklin MJ, Bazan JF, etal . A new nomenclature for IL-1-family genes. . Trends Immunol. . 22 . 10 . 536–7 . 2001 . 11574262 . 10.1016/S1471-4906(01)02040-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Hillier LW, Graves TA, Fulton RS, etal . Generation and annotation of the DNA sequences of human chromosomes 2 and 4. . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . free .

Notes and References

1. Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW . Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14 . J Interferon Cytokine Res . 21 . 11 . 899–904 . Dec 2001 . 11747621 . 10.1089/107999001753289505 .
2. Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE . Genomic organization of the interleukin-1 locus . Genomics . 79 . 5 . 726–33 . May 2002 . 11991723 . 10.1006/geno.2002.6752 .
3. Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K . A sequence-based map of the nine genes of the human interleukin-1 cluster . Genomics . 79 . 5 . 718–25 . May 2002 . 11991722 . 10.1006/geno.2002.6751 .
4. Web site: Entrez Gene: IL1F10 interleukin 1 family, member 10 (theta).