IL18BP explained

Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.^[1]

The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Three transcript variants encoding the same protein have been found for this gene.^[2]

Further reading

• Dinarello CA . Novel targets for interleukin 18 binding protein . Ann. Rheum. Dis. . 60 . Suppl 3. iii18–24 . 2002 . 11890646 . 10.1136/ard.60.90003.iii18 . 1766679 .
• Loughney K, Martins TJ, Harris EA, etal . Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases . J. Biol. Chem. . 271 . 2 . 796–806 . 1996 . 8557689 . 10.1074/jbc.271.2.796 . free .
• Aizawa Y, Akita K, Taniai M, etal . Cloning and expression of interleukin-18 binding protein . FEBS Lett. . 445 . 2–3 . 338–42 . 1999 . 10094485 . 10.1016/S0014-5793(99)00148-9 . 21572907 . free .
• Xiang Y, Moss B . Identification of human and mouse homologs of the MC51L-53L-54L family of secreted glycoproteins encoded by the Molluscum contagiosum poxvirus . Virology . 257 . 2 . 297–302 . 1999 . 10329540 . 10.1006/viro.1999.9676 . free .
• Kim SH, Eisenstein M, Reznikov L, etal . Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18 . Proc. Natl. Acad. Sci. U.S.A. . 97 . 3 . 1190–5 . 2000 . 10655506 . 10.1073/pnas.97.3.1190 . 15564 . 2000PNAS...97.1190K . free .
• Dias Neto E, Correa RG, Verjovski-Almeida S, etal . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 10.1073/pnas.97.7.3491 . 16267 . 2000PNAS...97.3491D . free .
• Michibata H, Yanaka N, Kanoh Y, etal . Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization . Biochim. Biophys. Acta . 1517 . 2 . 278–87 . 2001 . 11342109 . 10.1016/s0167-4781(00)00293-1.
• Paulukat J, Bosmann M, Nold M, etal . Expression and release of IL-18 binding protein in response to IFN-gamma . J. Immunol. . 167 . 12 . 7038–43 . 2001 . 11739524 . 10.4049/jimmunol.167.12.7038. free .
• Fidock M, Miller M, Lanfear J . Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants . Cell. Signal. . 14 . 1 . 53–60 . 2002 . 11747989 . 10.1016/S0898-6568(01)00207-8 .
• Corbaz A, ten Hove T, Herren S, etal . IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease . J. Immunol. . 168 . 7 . 3608–16 . 2002 . 11907126 . 10.4049/jimmunol.168.7.3608. free .
• Bufler P, Azam T, Gamboni-Robertson F, etal . A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity . Proc. Natl. Acad. Sci. U.S.A. . 99 . 21 . 13723–8 . 2002 . 12381835 . 10.1073/pnas.212519099 . 129755 . 2002PNAS...9913723B . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Hurgin V, Novick D, Rubinstein M . The promoter of IL-18 binding protein: Activation by an IFN-γ-induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein β . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16957–62 . 2003 . 12482935 . 10.1073/pnas.262663399 . 139251 . free .
• Plitz T, Saint-Mézard P, Satho M, etal . IL-18 binding protein protects against contact hypersensitivity . J. Immunol. . 171 . 3 . 1164–71 . 2003 . 12874202 . 10.4049/jimmunol.171.3.1164. free .
• Fantuzzi G, Banda NK, Guthridge C, etal . Generation and characterization of mice transgenic for human IL-18-binding protein isoform a . J. Leukoc. Biol. . 74 . 5 . 889–96 . 2004 . 12960225 . 10.1189/jlb.0503230 . 23024026 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Kawashima M, Novick D, Rubinstein M, Miossec P . Regulation of interleukin-18 binding protein production by blood and synovial cells from patients with rheumatoid arthritis . Arthritis Rheum. . 50 . 6 . 1800–5 . 2004 . 15188356 . 10.1002/art.20320 .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .

Notes and References

1. Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M . Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response . Immunity . 10 . 1 . 127–36 . Mar 1999 . 10023777 . 10.1016/S1074-7613(00)80013-8 . free .
2. Web site: Entrez Gene: IL18BP interleukin 18 binding protein.